Bioresorption of Porous 3D Matrices Based on Collagen in Liver and Muscular Tissue
- Authors: Popryadukhin P.V.1, Yukina G.Y.2, Dobrovolskaya I.P.3, Ivankova E.M.1, Yudin V.E.3
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Affiliations:
- Institute of Macromolecular Compounds
- Pavlov First St. Petersburg State Medical University
- Peter the Great St. Petersburg Polytechnic University
- Issue: Vol 12, No 3 (2018)
- Pages: 247-255
- Section: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212676
- DOI: https://doi.org/10.1134/S1990519X18030094
- ID: 212676
Cite item
Abstract
Highly porous cylinder-shaped 3D matrices with diameters of 1.3 and 3 mm were obtained by lyophilization of collagen solution. A study in vivo of the mechanism and rate of resorption of the resulting material showed that complete resorption of the matrix occurred 6 weeks after their implantation into liver tissue and 3 weeks after implantation into muscle tissue of animals. Surrounding tissues were not altered or damaged. Histological analysis revealed that, simultaneously with the resorption of matrix collagen, connective tissue and blood vessels were formed. This allows us to recommend the developed porous material based on collagen for use as matrices for tissue engineering and cellular transplantation.
About the authors
P. V. Popryadukhin
Institute of Macromolecular Compounds
Author for correspondence.
Email: pavel-pn@mail.ru
Russian Federation, St. Petersburg, 199004
G. Y. Yukina
Pavlov First St. Petersburg State Medical University
Email: pavel-pn@mail.ru
Russian Federation, St. Petersburg, 197022
I. P. Dobrovolskaya
Peter the Great St. Petersburg Polytechnic University
Email: pavel-pn@mail.ru
Russian Federation, St. Petersburg, 195251
E. M. Ivankova
Institute of Macromolecular Compounds
Email: pavel-pn@mail.ru
Russian Federation, St. Petersburg, 199004
V. E. Yudin
Peter the Great St. Petersburg Polytechnic University
Email: pavel-pn@mail.ru
Russian Federation, St. Petersburg, 195251