Bioresorption of Porous 3D Matrices Based on Collagen in Liver and Muscular Tissue
- 作者: Popryadukhin P.1, Yukina G.2, Dobrovolskaya I.3, Ivankova E.1, Yudin V.3
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隶属关系:
- Institute of Macromolecular Compounds
- Pavlov First St. Petersburg State Medical University
- Peter the Great St. Petersburg Polytechnic University
- 期: 卷 12, 编号 3 (2018)
- 页面: 247-255
- 栏目: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212676
- DOI: https://doi.org/10.1134/S1990519X18030094
- ID: 212676
如何引用文章
详细
Highly porous cylinder-shaped 3D matrices with diameters of 1.3 and 3 mm were obtained by lyophilization of collagen solution. A study in vivo of the mechanism and rate of resorption of the resulting material showed that complete resorption of the matrix occurred 6 weeks after their implantation into liver tissue and 3 weeks after implantation into muscle tissue of animals. Surrounding tissues were not altered or damaged. Histological analysis revealed that, simultaneously with the resorption of matrix collagen, connective tissue and blood vessels were formed. This allows us to recommend the developed porous material based on collagen for use as matrices for tissue engineering and cellular transplantation.
作者简介
P. Popryadukhin
Institute of Macromolecular Compounds
编辑信件的主要联系方式.
Email: pavel-pn@mail.ru
俄罗斯联邦, St. Petersburg, 199004
G. Yukina
Pavlov First St. Petersburg State Medical University
Email: pavel-pn@mail.ru
俄罗斯联邦, St. Petersburg, 197022
I. Dobrovolskaya
Peter the Great St. Petersburg Polytechnic University
Email: pavel-pn@mail.ru
俄罗斯联邦, St. Petersburg, 195251
E. Ivankova
Institute of Macromolecular Compounds
Email: pavel-pn@mail.ru
俄罗斯联邦, St. Petersburg, 199004
V. Yudin
Peter the Great St. Petersburg Polytechnic University
Email: pavel-pn@mail.ru
俄罗斯联邦, St. Petersburg, 195251