Induction of decidual differentiation in endometrial mesenchymal stem cells
- Authors: Domnina A.P.1, Novikova P.V.2, Fridlyanskaya I.I.1, Shilina M.A.1, Zenin V.V.1, Nikolsky N.N.1
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Affiliations:
- Institute of Cytology
- Faculty of Medicine
- Issue: Vol 10, No 2 (2016)
- Pages: 95-99
- Section: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212046
- DOI: https://doi.org/10.1134/S1990519X16020048
- ID: 212046
Cite item
Abstract
In this study, we compared the ability of human mesenchymal stem cells (eMSCs) derived from menstrual blood and mesenchymal stem cells (MSCs) from other tissues to differentiate into decidual cells in vitro. It was demonstrated that, during differentiation, secretion of prolactin and insulin-like growth factor binding protein-1 (key decidualization markers) markedly increased in eMSCs slightly augmented in bone marrow MSC (BM-MSCs) and did not change in MSCs from adipose tissue (AT-MSCs). Thus, eMSCs exhibited higher capacity for differentiation into decidual cells than BM-MSCs or AT-MSCs. This makes eMSCs promising for application in cellular therapy of infertility associated with insufficient decidualization of endometrium.
About the authors
A. P. Domnina
Institute of Cytology
Author for correspondence.
Email: aldomnina@mail.ru
Russian Federation, St. Petersburg, 194064
P. V. Novikova
Faculty of Medicine
Email: aldomnina@mail.ru
Russian Federation, St. Petersburg, 199034
I. I. Fridlyanskaya
Institute of Cytology
Email: aldomnina@mail.ru
Russian Federation, St. Petersburg, 194064
M. A. Shilina
Institute of Cytology
Email: aldomnina@mail.ru
Russian Federation, St. Petersburg, 194064
V. V. Zenin
Institute of Cytology
Email: aldomnina@mail.ru
Russian Federation, St. Petersburg, 194064
N. N. Nikolsky
Institute of Cytology
Email: aldomnina@mail.ru
Russian Federation, St. Petersburg, 194064