Induction of decidual differentiation in endometrial mesenchymal stem cells
- Авторлар: Domnina A.P.1, Novikova P.V.2, Fridlyanskaya I.I.1, Shilina M.A.1, Zenin V.V.1, Nikolsky N.N.1
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Мекемелер:
- Institute of Cytology
- Faculty of Medicine
- Шығарылым: Том 10, № 2 (2016)
- Беттер: 95-99
- Бөлім: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212046
- DOI: https://doi.org/10.1134/S1990519X16020048
- ID: 212046
Дәйексөз келтіру
Аннотация
In this study, we compared the ability of human mesenchymal stem cells (eMSCs) derived from menstrual blood and mesenchymal stem cells (MSCs) from other tissues to differentiate into decidual cells in vitro. It was demonstrated that, during differentiation, secretion of prolactin and insulin-like growth factor binding protein-1 (key decidualization markers) markedly increased in eMSCs slightly augmented in bone marrow MSC (BM-MSCs) and did not change in MSCs from adipose tissue (AT-MSCs). Thus, eMSCs exhibited higher capacity for differentiation into decidual cells than BM-MSCs or AT-MSCs. This makes eMSCs promising for application in cellular therapy of infertility associated with insufficient decidualization of endometrium.
Авторлар туралы
A. Domnina
Institute of Cytology
Хат алмасуға жауапты Автор.
Email: aldomnina@mail.ru
Ресей, St. Petersburg, 194064
P. Novikova
Faculty of Medicine
Email: aldomnina@mail.ru
Ресей, St. Petersburg, 199034
I. Fridlyanskaya
Institute of Cytology
Email: aldomnina@mail.ru
Ресей, St. Petersburg, 194064
M. Shilina
Institute of Cytology
Email: aldomnina@mail.ru
Ресей, St. Petersburg, 194064
V. Zenin
Institute of Cytology
Email: aldomnina@mail.ru
Ресей, St. Petersburg, 194064
N. Nikolsky
Institute of Cytology
Email: aldomnina@mail.ru
Ресей, St. Petersburg, 194064
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