Cycvalone in the synthesis of nitrogen-, oxygen-containing heterocycles
- Authors: Rogov D.A.1, Krivenko A.P.1
-
Affiliations:
- Saratov State University
- Issue: Vol 23, No 2 (2023)
- Pages: 159-165
- Section: Articles
- URL: https://journals.rcsi.science/1816-9775/article/view/251817
- DOI: https://doi.org/10.18500/1816-9775-2023-23-2-159-165
- EDN: https://elibrary.ru/BUMKGQ
- ID: 251817
Cite item
Full Text
Abstract
Cycvalone is an analogue of curcumin (EE conformation), exhibits a wide range of biological activity (antioxidant, hepatoprotective, membrane stabilizing, anti-ulcer) and is used in medical practice as a choleretic. Numerous methods of producing cycvalone are known, including industrial ones, but its reactions have been studied much less. Some reactions of cycvalone with N, C-nucleophiles (hydrazines, malononitrile) have been carried out. Reactions with getarylamines that could lead to the synthesis of compounds including pharmacophore fragments remained completely unexplored. We have used cycvalone as a substrate for the synthesis of nitrogen-, oxygen-containing heterosystems of a number of chromenopyrimidine, aminochromencarbonitrile, indazole, triazoloquinazoline. The structure of the obtained new substances has been established by spectral methods (IR, NMR). Schemes of formation of reaction products have been proposed.
About the authors
Danila A. Rogov
Saratov State University
ORCID iD: 0009-0002-7395-0173
83, Astrakhanskaya str., Saratov, 410012, Russia
Adel P. Krivenko
Saratov State University83, Astrakhanskaya str., Saratov, 410012, Russia
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