Surgical treatment of trophoblastic disease. Modern concept and contradictions (literature review)

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Abstract

A review of studies on the comparison of the effectiveness of surgical treatment of malignant trophoblastic tumors before the start of standard chemotherapy and in terms of combination treatment is presented. According to Russian and foreign studies, surgical treatment is relevant for patients with primary or metastatic tumor resistance. The article presents the results of treatment of patients after various types of operations. The most common volume of surgery was a hysterectomy. The article also discusses the results of treatment of benign forms of trophoblastic disease. Surgical treatment of a malignant trophoblastic tumor before the start of standard chemotherapy was performed according to vital indications or in connection with a tumor determined by imaging methods. And the analysis carried out in Blokhin National Medical Research Center of Oncology showed expected prognoses for patients who underwent surgical treatment prior to the start of standard chemotherapy regimens. Such patients were admitted to the clinic with a resistant or disseminated form of the tumor. During their treatment, high-dose chemotherapy or additional surgical interventions were required, which significantly worsened the prognosis of the disease. In the opposite case, when removing a localized resistant primary tumor or its metastasis, in the postoperative period, chemotherapy was not carried out in connection with marker remission.

About the authors

Aleksandr F. Maslennikov

Blokhin National Medical Research Center of Oncology

Author for correspondence.
Email: rihterfm@mail.ru
ORCID iD: 0000-0003-3959-3133

Graduate Student

Russian Federation, Moscow

Liudmila A. Meshcheriakova

Blokhin National Medical Research Center of Oncology

Email: 2010am@mail.ru
ORCID iD: 0000-0003-0770-3406

D. Sci. (Med.)

Russian Federation, Moscow

Viktor V. Kuznetsov

Blokhin National Medical Research Center of Oncology

Email: abgadzhiev@yandex.ru
ORCID iD: 0000-0003-1535-973X

D. Sci. (Med.), Prof.

Russian Federation, Moscow

Vladimir P. Kozachenko

Blokhin National Medical Research Center of Oncology

Email: kozachek@mail.ru

D. Sci. (Med.), Prof., Acad. RANS

Russian Federation, Moscow

Igor G. Komarov

Blokhin National Medical Research Center of Oncology

Email: komarovig@mail.ru
ORCID iD: 0000-0002-3495-5521

D. Sci. (Med.), Prof.; Russian Medical Academy of Continuous Professional Education

Russian Federation, Moscow

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