The use of low molecular weight heparin Enixum® in the prevention and treatment of thrombosis in oncology

Thromboembolic complications often develop in patients with various forms of malignant neoplasms, and the occurrence of thromboses complicates antitumor treatment and worsens the survival rates of patients. In modern studies it has been shown that oncological disease increases the risk of developing thrombotic complications 4-7 times. The leading role in the pathogenesis of thrombotic complications in patients with malignant neoplasms is played by changes in the hemostatic system, caused both by the tumor itself and by treatment methods. At present, low molecular weight heparins are the main drugs in the prevention and treatment of thrombotic complications in cancer patients. Anticoagulant of direct action of domestic production - Enixum® (Pharmfirma Soteks, Russia, registration certificate No. ЛП-002330) in chemical structure is sodium enoxaparin, according to pharmacokinetic and pharmacodynamic properties it corresponds to the original drug - Clexan® (Sanofi Winthrop Industry, France). An open comparative randomized multicenter clinical trial in Russia of the drug Enixum® and Clexan® in patients with a high risk of thrombotic/thromboembolic complications in the postoperative period showed that the efficacy and safety of the Enixum® product is equivalent to the efficacy and safety of the Clexan® drug. The use of Enixum® for the prevention of thrombotic complications in the postoperative period in oncogynecologic patients and in the treatment of acute thromboses and PE during various stages of complex treatment has proved the high efficacy and safety of this low molecular weight heparin.

oncological patients, thrombotic complications, low molecular weight heparins, Enixum® (sodium enoxaparin)