Latent herpes virus infection in the carcinogenesis of bladder cancer


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Abstract

This article discusses the basic mechanisms of latency some of the herpes viruses and the role of persistence of these viruses in oncogenesis. A statistically significant increase of the level of viral antibodies in patients with recurrent, locally advanced bladder cancer with high potential of malignancy; the statistically significant correlations between the presence of viral DNA cytomegalovirus and Epstein-Barr virus in the tumor and the level of antibodies, the stage of the process and recurrent nature of the tumor were found. The presence of viral DNA in the tumor was determined in 30% of cases.

About the authors

O B Loran

Russian Medical Academy of Postgraduate Education of the Ministry of Health of the Russian Federation

Email: oleg_loran@gmail.com
чл.-кор. РАН, д-р мед. наук, проф. каф. урологии и хирургической андрологии ГБОУ ДПО РМАПО 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

L A Sinyakova

Russian Medical Academy of Postgraduate Education of the Ministry of Health of the Russian Federation

Email: l.a.sinyakova@mail.ru
д-р мед. наук, проф. каф. урологии и хирургической андрологии ГБОУ ДПО РМАПО 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

L V Gundorova

City Clinical Hospital №68 of the Department of Health of Moscow

Email: ludovik-213@mail.ru
д-р мед. наук, зав. патологоанатомическим отд-нием ГБУЗ ГКБ №68 109263, Russian Federation, Moscow, ul. Shkuleva, d. 4

V A Kosov

Komi Republican Oncologic Hospital

Email: zinaidakosova@yandex.ru
врач уролог-онколог, вед. cпециалист ГУ КРОД 167904, Russian Federation, Syktyvkar, pgt Krasnozatonskii, Niuvchimskoe shosse, d. 46

I V Kosova

City Clinical Hospital №68 of the Department of Health of Moscow

Email: kosovainga@mail.ru
канд. мед. наук, врач-уролог урологического отд-ния ГБУЗ ГКБ №68 109263, Russian Federation, Moscow, ul. Shkuleva, d. 4

D N Kolbasov

City Clinical Hospital №68 of the Department of Health of Moscow

Email: urology68@rambler.ru
канд. мед. наук, врач-уролог, зав. урологическим отд-нием ГБУЗ ГКБ №68 109263, Russian Federation, Moscow, ul. Shkuleva, d. 4

I V Kononkov

City Clinical Hospital №68 of the Department of Health of Moscow

Email: urology68@rambler.ru
врач-уролог урологического отд-ния ГБУЗ ГКБ №68 109263, Russian Federation, Moscow, ul. Shkuleva, d. 4

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