Gefitinib – terapiya vybora 1-y linii nemelkokletochnogo raka legkogo u bol'nykh s nalichiem mutatsiy v gene EGFR


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Abstract

С позиций современных знаний о роли мутаций определенных генов и связанной с этим эффективностью лекарственной терапии необходимо проведение генетических исследований для рационального выбора 1-й линии лечения. Применение ингибиторов тирозинкиназы у больных с наличием мутации EGFR в 1-й линии терапии больных немелкоклеточным раком легкого позволяет добиться достоверного увеличения медианы до прогрессирования заболевания при меньшей токсичности проводимого лечения у грамотно отобранной когорты больных.

About the authors

Larisa Vladimirovna Bolotina

ФГБУ Московский научно-исследовательский онкологический институт им. П.А.Герцена Минздрава РФ

д-р мед. наук, рук. отд-ния химиотерапии

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