Bevatsizumab v kombinatsii s khimioluchevoy terapiey u bol'nykh glioblastomoy


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Abstract

Представлен обзор литературы по клиническим исследованиям II и III фазы, изучавшим эффективность и безопасность использования бевацизумаба в комбинации с химиолучевой терапией у больных с впервые диагностированной глиобластомой головного мозга. Приведены данные о статистически значимом увеличении выживаемости без прогрессирования у больных глиобластомой на 4,4 мес и снижении относительного риска прогрессирования или смерти на 36% при применении бевацизумаба в комбинации со стандартной химиолучевой терапией у больных с вновь диагностированной глиобластомой. Показано, что добавление бевацизумаба достоверно увеличивает время до ухудшения статуса Карновского, статуса общего здоровья, физического, социального функционирования, моторного и коммуникационного дефицита. Оценена безопасность применения бевацизумаба в комбинации с химиолучевой терапией. Освещены возможные показания к применению бевацизумаба в 1-й линии терапии, приведены данные собственного опыта применения бевацизумаба по этим показаниям.

About the authors

Aleksey Vladimirovich Smolin

ФГКУ Главный военный клинический госпиталь им. акад. Н.Н.Бурденко Минобороны России

нач. Радиологического центра

Andrey Vladimirovich Konev

ФГКУ Главный военный клинический госпиталь им. акад. Н.Н.Бурденко Минобороны России

зав. 31-м радиологическим (терапевтическим) отд-нием

Grigoriy L'vovich Kobyakov

НИИ нейрохирургии им. Н.Н.Бурденко РАМН

рук. группы химиотерапии опухолей ЦНС 7-го отд-ния

Svetlana Nikolaevna Nikolaeva

ФГКУ Главный военный клинический госпиталь им. акад. Н.Н.Бурденко Минобороны России

врач-радиолог 31-го радиологического (терапевтического) отд-ния

Yuliya Evgen'evna Shamanskaya

ФГКУ Главный военный клинический госпиталь им. акад. Н.Н.Бурденко Минобороны России

врач-радиолог 31-го радиологического (терапевтического) отд-ния

Aleksey Valer'evich Gorbunov

ФГКУ Главный военный клинический госпиталь им. акад. Н.Н.Бурденко Минобороны России

врач отд-ния МРТ

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