Problemy endokrinoterapii raka molochnoy zhelezy u muzhchin


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Abstract

Рак молочной железы (РМЖ) у мужчин встречается редко и составляет примерно 1% всех случаев РМЖ. Количество наблюдений как у отдельных исследователей, так и в крупных научных центрах невелико и чрезвычайно растянуто во времени. При анализе эффективных методов лечения, как правило, используется только исторический контроль, а рандомизированные исследования отсутствуют. Многие постулаты алгоритма лечения взяты из практики лечения РМЖ у женщин. Между тем в ряде случаев прямая экстраполяция тактики терапии некорректна, так как помимо сходства имеется ряд различий в болезни у женщин и мужчин.В первом крупном отечественном исследовании РМЖ у мужчин на основании анализа результатов лечения 55 больных сделан обоснованный вывод о гормональной зависимости опухоли. Позднее была четко определена зависимость эффекта гормонотерапии от уровня рецепторов эстрогена в опухоли и роль тамоксифена в лечении РМЖ у мужчин

About the authors

E I Borisova

ГУ Российский онкологический научный центр им. Н.Н.Блохина РАМН

I Yu Voronina

ГУ Российский онкологический научный центр им. Н.Н.Блохина РАМН

S L Gutorov

ГУ Российский онкологический научный центр им. Н.Н.Блохина РАМН

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