Email this article Experience with the combination of tixagevimab + cilgavimab for pre-exposure prophylaxis of COVID-19 in cancer patients: A retrospective analysis
- Authors: Lyadova M.A.1,2, Fedorinov D.S.1,3, Kuzmina E.S.1, Antonova T.G.1, Sokolskaya V.K.1
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Affiliations:
- Moscow State Budgetary Healthcare Institution "Moscow City Oncological Hospital No.1, Moscow Healthcare Department"
- Novokuznetsk State Institute for the Advanced Training of Doctors – branch of the Russian Medical Academy of Continuous Professional Education
- Russian Medical Academy of Continuous Professional Education
- Issue: Vol 25, No 3 (2023)
- Pages: 392-396
- Section: CLINICAL ONCOLOGY
- URL: https://journals.rcsi.science/1815-1434/article/view/148907
- DOI: https://doi.org/10.26442/18151434.2023.3.202456
- ID: 148907
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Abstract
Background. COVID-19 (COrona VIrus Disease 2019) is a serious threat to cancer patients, who are at an increased risk of severe infection complications. Pre-exposure prophylaxis with a combination of monoclonal antibodies, tixagevimab-cilgavimab (Evusheld), has been shown to be effective in preventing COVID-19, reducing hospital admission rate and mortality in immunocompromised individuals.
Aim. To describe the experience of using tixagevimab-cilgavimab for pre-exposure prophylaxis of COVID-19 in the Russian population of patients with solid tumors receiving antitumor drug therapies.
Materials and methods. The retrospective analysis included case histories of 79 patients (57% females and 43% males) with solid tumors treated at the Moscow City Clinical Oncology Hospital No. 1 from October 2022 to June 2023. All patients received tixagevimab-cilgavimab for COVID-19 pre-exposure prophylaxis.
Results. The mean age was 64±11 years (32 to 83 years). Seventy-three percent of patients received cytotoxic therapy, associated with an increased risk of infectious complications, including COVID-19. No immediate or delayed adverse events related to tixagevimab-cilgavimab were reported. During the observation period since the drug injection, 3 (3.8%) new mild cases of COVID-19 were reported.
Conclusion. Tixagevimab-cilgavimab (Evusheld) is safe and effective for pre-exposure prophylaxis of COVID-19 in the Russian population of patients with solid tumors receiving antitumor drug therapy.
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##article.viewOnOriginalSite##About the authors
Marina A. Lyadova
Moscow State Budgetary Healthcare Institution "Moscow City Oncological Hospital No.1, Moscow Healthcare Department"; Novokuznetsk State Institute for the Advanced Training of Doctors – branch of the Russian Medical Academy of Continuous Professional Education
Author for correspondence.
Email: dr.lyadova@gmail.com
ORCID iD: 0000-0002-9558-5579
cand. sci. (med.)
Russian Federation, Moscow; NovokuznetskDenis S. Fedorinov
Moscow State Budgetary Healthcare Institution "Moscow City Oncological Hospital No.1, Moscow Healthcare Department"; Russian Medical Academy of Continuous Professional Education
Email: deni_fe@mail.ru
ORCID iD: 0000-0001-5516-7367
oncologist
Russian Federation, MoscowEvgeniya S. Kuzmina
Moscow State Budgetary Healthcare Institution "Moscow City Oncological Hospital No.1, Moscow Healthcare Department"
Email: kuz011@mail.ru
ORCID iD: 0009-0007-2856-5176
chemotherapy department head
Russian Federation, MoscowTatiana G. Antonova
Moscow State Budgetary Healthcare Institution "Moscow City Oncological Hospital No.1, Moscow Healthcare Department"
Email: tattg@mail.ru
ORCID iD: 0009-0007-6646-7454
chemotherapy day care center head
Russian Federation, MoscowValentina K. Sokolskaya
Moscow State Budgetary Healthcare Institution "Moscow City Oncological Hospital No.1, Moscow Healthcare Department"
Email: sddv1@yandex.ru
deputy chief doctor
Russian Federation, MoscowReferences
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