THE ROLE OF SALIVARY GLAND BIOPSY IN DIAGNOSIS OF SYSTEMIC DISEASES AND THEIR LYMPHOPROLIFERATIVE COMPLICATIONS


Cite item

Full Text

Abstract

The clinical picture of many systemic diseases (SD) could make its debut in the maxillofacial area with salivary gland lesions. Sjogren’s sicca syndrome, IgG4-related diseases, sarcoidosis, viral hepatitis - C, primary biliary cirrhosis, autoimmune hepatitis, as well as complications of the plurality of abnormalities in the form of lymphoproliferative diseases including AL-amyloidosis and B-cell lymphomas of different malignant tumors. The main diagnostic criteria in this case are the data of histological and immunohistochemistry studies of affected tissues. The aim of this publication is to analyze literature data on the pathological changes developing in salivary glands at different SD. The question about the diagnostic value of limphoplazmatsitarny infiltrate detected in the salivary gland biopsy materials SD and its influence on the prognosis and course of pathological process remains open. Conclusions: salivary glands biopsy has played a significant role in the early diagnosis and follow-up of patients with a variety of SD occurring with salivary gland lesions and such research studies have been required to continue.

About the authors

Ekaterina Borisovna Rodionova

FGBNU «Research Institute of Rheumatology named by V.A. Nasonova»

Email: kate.76@mail.ru
cand. med. sci., dental therapist 115522, Moscow

References

  1. Ромачева И.Ф., Юдин Л.А., Афанасьев В.В., Морозов А.Н. Заболевания и повреждения слюнных желез. М.: Медицина; 1987.
  2. Афанасьев В.В. Слюнные железы. Болезни и травмы. Руководство для врачей. М.: ГЭОТАР-Медиа; 2012.
  3. Денисов А.Б. Слюнные железы и слюна. М.: Издательство РАМН; 2003.
  4. Myers E.N., Ferris R.L. et al. Salivary Gland Disorders. Springer; 2007. doi: 10.1007/978-3-540-47072-4
  5. Mikulicz J. Uber eine eigenartige symmetrische Erkrankung der Tranen - und Mundspeicheldrusen. Stuttgart: Beitr z Chir Fetscrf Theodor Billroth; 1892: 610-30.
  6. Kuttner H. Ueber entzundliche tumoren der subm axillar - speicheldruse. Beitr. Klin. Chir. 1896; 15: 815-34.
  7. Seifert G., Geiler G. Speicheldrusen und Rheumatismus. Deut. Med. Wschr. 1957; 82: 1415-7.
  8. Васильев В.И., Симонова М.В., Сафонова Т.Н. Критерии диагноза болезни и синдрома Шегрена. В кн.: В.А.Насонова, Н.В.Бунчук, ред. Избранные лекции по клинической ревматологии. М.: Медицина; 2001: 110-32.
  9. Cафонова Т.Н., Васильев В.И., Лихванцева В.Г. Синдром Шегрена. Руководство для врачей. М.: Издательство Московского университета; 2013.
  10. Bloch K., Buchanan W., Wohl M., Bunim J. Sjögrenʼs syndrome. Medicine. 1965; 44 (3): 187-231. doi: 10.1097/00005792-196505000-00001
  11. Marx R.E., Hartman K.S., Rethman K.V. A prospective study comparing incisional labial to incisional parotid biopsies in the detection and confirmation of sarcoidosis, Sjogren’s syndrome, sialosis and lymphoma. J. Rheumathol. 1988; 15 (4): 621-9.
  12. Митриков Б.В., Панин A.M., Гайдук И.В., Панин М.Г., Васильев В.И., Симонова М.В. и др. Лимфоэпителиальные поражения слюнных желез у пациентов с болезнью Шегрена - клинико-морфологические аспекты диагностики. Медицинская помощь. 2008; 3: 29-31
  13. Chisholm D., Waterhouse J., Mason D. Lymphocytic sialadenitis in the major and minor glands: a correlation in postmortem subjects. J. Clinical Pathology. 1970; 23 (8): 690-4. doi: 10.1136/jcp.23.8.690.
  14. Cifarelli P. Sjogren’s Syndrome. Arch. Internal Med. 1966; 117 (3): 429. doi: 10.1001/archinte.1966.03870090113022.
  15. van Stein-Callenfels D., Tan J., Bloemena E., van Vugt R.M., Voskuyl A.E., Nathalie T.Y., Santana et al. The role of a labial salivary gland biopsy in the diagnostic procedure for Sjögren’s syndrome: a study of 94 cases. Med. Oral Patol. Oral Cir. Bucal. 2014; 19 (4): e372-6. doi: 10.4317/medoral.20010
  16. Fox R., Robinson C., Curd J., Kozin F., Howelly F. Sjögren’s syndrome. Proposed criteria for classification. Arthrit. Rheumat. 1986; 29 (5): 577-85. doi: 10.1002/art.1780290501
  17. Vitali C. Classification criteria for Sjogren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann. Rheumat. Diseas. 2002; 61 (6): 554-8. doi: 10.1136/ard.61.6.554.
  18. Vitali C., Bombardieri S., Moutsopoulos H. et al. Assessment of the European classification criteria for Sjogren’s syndrome in a series of clinically defined cases: results of a prospective multicentre study. The European Study Group on Diagnostic Criteria for Sjogren’s Syndrome. Ann. Rheumat. Diseas. 1996; 55 (2): 116-21. doi: 10.1136/ard.55.2.116.
  19. Shiboski S., Shiboski C., Criswell L. et al. American College of Rheumatology classification criteria for Sjögren’s syndrome: A data-driven, expert consensus approach in the Sjögren’s International Collaborative Clinical Alliance Cohort. Arth. Care Res. 2012; 64 (4): 475-87. doi: 10.1002/acr.21591.
  20. Greenspan J., Daniels T., Talal N., Sylvester R. The histopathology of Sjögren’s syndrome in labial salivary gland biopsies. Oral Surg. Oral Med. Oral Path. 1974; 37 (2): 217-29. doi: 10.1016/0030-4220 (74)90417-4.
  21. Daniels T., Cox D., Shiboski C. et al. Associations between salivary gland histopathologic diagnoses and phenotypic features of Sjögren’s syndrome among 1,726 registry participants. Arth. Rheumat. 2011; 63 (7): 2021-30. doi: 10.1002/art.30381.
  22. Radfar L., Kleiner D., Fox P., Pillemer S. Prevalence and clinical significance of lymphocytic foci in minor salivary glands of healthy volunteers. Arthr. Rheumat. 2002; 47 (5): 520-4. doi: 10.1002/art.10668.
  23. Lindahl G., Lefvert Ann-Kari. Periductal lympocytic infiltrates in salivary glands im myasthenia gravis patients lacking Sjogren’s syndrome. Clin. Exp. Immunol. 1986; 66: 95-102.
  24. Pijpe J., Kalk W., van der Wal J. et al. Parotid gland biopsy compared with labial biopsy in the diagnosis of patients with primary Sjogren’s syndrome. Rheumatol. 2006; 46 (2): 335-41. doi: 10.1093/rheumatology/kel266.
  25. Talal N., Moutsopoulos H.M. et al. Sjogren’s Syndrome. Clinical and Immunological Aspects. S.S. Kassan. Springer-Verlag. 1987. doi.10.1007/978-3-642-50118-0
  26. Helenius L. Focal sialadenitis in patients with ankylosing spondylitis and spondyloarthropathy: a comparison with patients with rheumatoid arthritis or mixed connective tissue disease. Ann. Rheumat. Dis. 2001; 60 (8): 744-9. doi: 10.1136/ard.60.8.744.
  27. Flipo R., Janin A., Hachulla E. et al. Labial salivary gland biopsy assessment in rheumatoid vasculitis. Ann. Rheumat. Dis. 1994; 53 (10): 648-52. doi: 10.1136/ard.53.10.648.
  28. Skopouli F., Siouna-Fatourou H., Dimou G., Galanopoulou D., Papadimitriou C., Moutsopoulos H. Histologic lesion in labial salivary glands of patients with systemic lupus erythematosus. Oral Surg. Oral Med. Oral Path. 1991; 72 (2): 208-12. doi: 10.1016/0030-4220 (91)90165-9.
  29. Васильев В.И., Логвиненко О.А., Пробатова Н.А. и др. Роль биопсии околоушной слюнной железы в ранней диагностике лимфом при болезни Шегрена. Терапевтический архив. 2009; 6: 20-7
  30. Ekstrom Smedby K., Vajdic C., Falster M. et al. Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium. Blood. 2008; 111 (8): 4029-38. doi: 10.1182/blood-2007-10-119974
  31. Логвиненко О.А., Васильев В.И. Неходжкинские лимфомы при ревматических заблеваниях. Научно-практическая ревматология. 2011; 49 (5): 71-82. doi: 10.14412/1995-4484-2011-1464
  32. Nunes H., Bouvry D., Soler P., Valeyre D. Sarcoidosis. Orphanet J. Rare Dis. 2007; 2 (1): 46. doi: 10.1186/1750-1172-2-46.
  33. Chevalet P., Clément R., Rodat O., Moreau A., Brisseau J., Clarke J. Sarcoidosis Diagnosed in Elderly Subjects. Chest. 2004; 126 (5): 1423-30. doi: 10.1378/chest.126.5.1423.
  34. Боровская А.Б., Гайдук И.В., Панин А.М., Васильев В.И., Седышев С.Х., Кокосадзе Н.В. Саркоидоз в практик врача-стоматолога. Dental Forum. 2013; 48 (2): 49-52
  35. Greenberg G., Anderson R., Sharpstone P., James D. Enlargement of Parotid Gland Due to Sarcoidosis. BMJ. 1964; 5413 (2): 861-2. doi: 10.1136/bmj.2.5413.861
  36. Васильев В.И., Логвиненко О.А., Симонова М.В. и др. Развитие сухого синдрома при саркоидозе с поражением слюнных и слезных желез. Терапевтический архив. 2005; 77 (1): 62-7
  37. Giotaki H., Constantopoulos S., Papadimitriou C., Moutsopoulos H. Labial Minor Salivary Gland Biopsy: a Highly Discriminatory Diagnostic Method between Sarcoidosis and Sjögren’s Syndrome. Respiration. 2009; 50 (2): 102-7. doi: 10.1159/000194916.
  38. Drosos A., Voulgari P., Psychos D., Tsifetaki N., Bai M. Sicca syndrome in patients with sarcoidosis. Rheumatol. Intern. 1999; 18 (5-6): 177-80. doi: 10.1007/s002960050081.
  39. Brincker H., Wilbek E. The Incidence of Malignant Tumours in Patients with Respiratory Sarcoidosis. Brit. J. Cancer. 1974; 29 (3): 247-51. doi: 10.1038/bjc.1974.64.
  40. Brincker H. The sarcoidosis-lymphoma syndrome. Brit. J. Cancer. 1986; 54 (3): 467-73. doi: 10.1038/bjc.1986.199.
  41. Trier Hchristensen M. Hodgkin’s Disease in Sarcoidosis: A Case Report and a Review of the Literature. Act. Med. Scand. 2009; 218 (1): 137-40. doi: 10.1111/j.0954-6820.1985.tb08838.x.
  42. Karakantza M., Matutes E., MacLennan K., O’Connor N., Srivastava P., Catovsky D. Association between sarcoidosis and lymphoma revisited. J. Clin. Pathol. 1996; 49 (3): 208-12. doi: 10.1136/jcp.49.3.208.
  43. Hermann C., Andersen E., Videbaek A. Acute Myeloblastic Leukaemia in Sarcoidosis Treated with Methotrexate. Scand. J. Haematol. 2009; 24 (3): 234-6. doi: 10.1111/j.1600-0609.1980.tb01331.x.
  44. Serratrice J., Granel B., Swiader L. et al. Sarcoidosis Preceding Chronic Myelomonocytic Leukemia. Dermatology. 2002; 205 (4): 409-12. doi: 10.1159/000066420
  45. Pettersson T., Koivunen E., Ilvonen M., Jouppila J., Aalto E., Wasastjerna C. Sarcoidosis and multiple myeloma: an association. BMJ. 1987; 295 (6604): 958. doi: 10.1136/bmj.295.6604.958.
  46. Wirk Sarcoid Reactions after Chemotherapy for Hodgkin’s Lymphoma. Clinical Medicine Insights: Case Rep. 2010: 21. doi: 10.4137/ccrep.s5243.
  47. Beyer G., Schwaiger T., Lerch M., Mayerle J. IgG4-related disease: a new kid on the block or an old aquaintance? United Eur. Gastroenterol. J. 2014; 2 (3): 165-72. doi: 10.1177/2050640614532457.
  48. Masaki Y., Shimizu H., Sato Nakamura T. et al. IgG4-Related Disease: Diagnostic Methods and Therapeutic Strategies in Japan. J. Clin. Exp. Hematopathol. 2014; 54 (2): 95-101. doi: 10.3960/jslrt.54.95.
  49. Masaki Y., Sugai S., Umehara H. IgG4-related Diseases Including Mikulicz’s Disease and Sclerosing Pancreatitis: Diagnostic Insights. J. Rheumatol. 2010; 37 (7): 1380-5. doi: 10.3899/jrheum.091153.
  50. Divatia M., Kim S., Ro J. IgG4-Related Sclerosing Disease, an Emerging Entity: A Review of a Multi-System Disease. Yonsei Med. J. 2012; 53 (1): 15. doi: 10.3349/ymj.2012.53.1.15.
  51. Takano K., Yamamoto M., Takahashi H., Shinomura Y., Imai K., Himi T. Clinicopathologic similarities between Mikulicz disease and Küttner tumor. Am. J. Otolaryngol. 2010; 31 (6): 429-34. doi: 10.1016/j.amjoto.2009.08.002.
  52. Васильев В.И., Сокол Е.В., Родионова Е.Б. Связанные IgG4 - поражения слюнных желез. Терапевтический архив. 2015; 87 (8): 92. doi: 10.17116/terarkh201587892-102
  53. Geyer J., Ferry J., Harris N. et al. Chronic Sclerosing Sialadenitis (Küttner Tumor) Is an IgG4-associated Disease. Am. J. Surg. Pathol. 2010; 34 (2): 202-10. doi: 10.1097/pas.0b013e3181c811ad.
  54. Martínez Consuegra N., Baquera Heredia J., Sánchez Cisneros R., Márquez Rocha M., Ortiz-Hidalgoa C. Küttner’s Tumour (Chronic Sclerosing Sialadenitis). Clinical, Pathological, and Immunohistochemical Study in 8 Cases of a Little-Known Entity. Act. Otorinolaringol. (English Ed.). 2007; 58 (1): 25-30. doi: 10.1016/s2173-5735 (07)70295-8.
  55. Masaki Y., Kurose N., Umehara H. IgG4-Related Disease: A Novel Lymphoproliferative Disorder Discovered and Established in Japan in the 21st Century. J. Clin. Exp. Hematopathol. 2011; 51 (1): 13-20. doi: 10.3960/jslrt.51.13.
  56. Paul R., Shekar K., Singh M. Kuttner tumour: an unusual cause of enlargement of a minor salivary gland in the lip. Brit. J. Oral Maxillofacial Surg. 2010; 48 (2): 152-3. doi: 10.1016/j.bjoms.2009.07.029.
  57. Morgan W.S., Castleman B.A. Clinical of “Mikulicz’s Disease: Clinicopathologic study. American J. Pathol. 1953; 29: 471-503.
  58. Симонова М.В., Васильев В.И., Корнилова Н.Н. и др. Дифференциальная диагностика болезни Микулича и болезни Шегрена. Стоматология. 1988; 3: 71-3
  59. Yamamoto M., Takahashi H., Tabeya T. et al. Risk of malignancies in IgG4-related disease. Modern Rheumatol. 2011; 22 (3): 414-8. doi: 10.1007/s10165-011-0520-x.
  60. Takahashi N., Ghazale A., Smyrk T., Mandrekar J., Chari S. Possible Association Between IgG4-Associated Systemic Disease With or Without Autoimmune Pancreatitis and non-Hodgkin Lymphoma. Pancreas. 2009; 38 (5): 523-6. doi: 10.1097/mpa.0b013e31819d73ca.
  61. Verbaan H., Carlson J., Eriksson S. et al. Extrahepatic manifestations of chronic hepatitis C infection and the interrelationship between primary Sjogren’s syndrome and hepatitis C in Swedish patients. J. Intern. Med. 1999; 245 (2): 127-32. doi: 10.1046/j.1365-2796.1999.00414.x.
  62. Cacoub P., Renou C., Rosenthal E. et al. Extrahepatic Manifestations Associated with Hepatitis C Virus Infection: A Prospective Multicenter Study of 321 Patients. Medicine. 2000; 79 (1): 47-56. doi: 10.1097/00005792-200001000-00005.
  63. Carrozzo M., Gandolfo S. Oral diseases possibly associated with hepatitis C virus. Critical Rev. Oral Biol. Med. 2003; 14 (2): 115-27. doi: 10.1177/154411130301400205.
  64. Vitali C. Immunopathologic differences of Sjögren’s syndrome versus sicca syndrome in HCV and HIV infection. Arth. Res. Ther. 2011; 13 (4): 233. doi: 10.1186/ar3361.
  65. Pawlotsky J. Extrahepatic Immunologic Manifestations in Chronic Hepatitis C and Hepatitis C Virus Serotypes. Ann. Intern. Med. 1995; 122 (3): 169. doi: 10.7326/0003-4819-122-3-199502010-00002.
  66. Coll J., Gambus G., Corominas J., Tomas S., Esteban J., Guardia J. Immunohistochemistry of minor salivary gland biopsy specimens from patients with Sjogren’s syndrome with and without hepatitis C virus infection. Ann. Rheumat. Dis. 1997; 56 (6): 390-2. doi: 10.1136/ard.56.6.390.
  67. Ramos-Casals M., García-Carrasco M., Cervera R. et al. Hepatitis C Virus Infection Mimicking Primary Sjögren Syndrome. Medicine. 2001; 80 (1): 1-8. doi: 10.1097/00005792-200101000-00001.
  68. Пальшина С.Г., Васильев В.И. Криоглобулинемический васкулит. Научно-практическая ревматология. 2010; 4: 59-66
  69. Saadoun D., Landau D., Calabrese L., Cacoub P. Hepatitis C-associated mixed cryoglobulinaemia: a crossroad between autoimmunity and lymphoproliferation. Rheumatol. 2007; 46 (8): 1234-42. doi: 10.1093/rheumatology/kem132.
  70. Pozzato G. Hepatitis C virus and non-Hodgkin’s lymphomas: Meta-analysis of epidemiology data and therapy options. World J. Hepatol. 2016; 8 (2): 107. doi: 10.4254/wjh.v8.i2.107.
  71. Marcucci F Mele A. Hepatitis viruses and non-Hodgkin lymphoma: epidemiology, mechanisms of tumorigenesis, and therapeutic opportunities. Blood. 2010; 117 (6): 1792-8. doi: 10.1182/blood-2010-06-275818.
  72. Monti G., Pioltelli P., Saccardo F. et al. Incidence and Characteristics of Non-Hodgkin Lymphomas in a Multicenter Case File of Patients With Hepatitis C Virus-Related Symptomatic Mixed Cryoglobulinemias. Arch. Intern. Med. 2005; 165 (1): 101. doi: 10.1001/archinte.165.1.101
  73. Ramos-Casals M., Civita L., de Vita S. et al. Characterization of B cell lymphoma in patients with Sjögren’s syndrome and hepatitis C virus infection. Arth. Rheumat. 2007; 57 (1): 161-70. doi: 10.1002/art.22476.
  74. Rosenzweig M., Landau H., Seldin D. et al. Cancer-testis antigen expression and immunogenicity in AL amyloidosis. Blood Cancer J. 2012; 2 (9): e90. doi: 10.1038/bcj.2012.32.
  75. Desport E., Bridoux F., Sirac C. et al. AL Amyloidosis. Orph. J. Rare Dis. 2012; 7 (1): 54. doi: 10.1186/1750-1172-7-54.
  76. Cohen A., Connors L. The pathogenesis and biochemistry of amyloidosis. J. Pathol. 1987; 151 (1): 1-10. doi: 10.1002/path.1711510102.
  77. Васильев В.И., Городецкий В.Р., Раденска-Лоповок С.Г. и др. Новые подходы к определению органных поражений при AL-амилоидозе. Научно-практическая ревматология. 2012; 50 (1): 83-90. doi: 10.14412/1995-4484-2012-510
  78. Prokaeva T., Spencer B., Kaut M. et al. Soft tissue, joint, and bone manifestations of AL amyloidosis: Clinical presentation, molecular features, and survival. Arth. Rheumat. 2007; 56 (11): 3858-68. doi: 10.1002/art.22959
  79. Рыжко В.В., Клодзинский А.А., Варламова Е.Ю., и др. Сложности диагностики AL-амилоидоза: обзор литературы и собственные наблюдения. Клиническая онкогематология. 2009; 2 (1): 47-55

Copyright (c) 2017 Eco-Vector


 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies