Clinical effectiveness of comprehensive evaluation of soft tissue inflammation during preparation and treatment by dental implantation: A case report

At the Department of Orthopedic Dentistry and Orthodontics of the Ryazan State Medical University, one patient (A.) underwent after tooth extraction at the orthopedic rehabilitation using immediate prosthetics, and another patient (B.) was cured after extraction proceeded naturally. Both patients underwent dental implantation 4 months later. After tooth extraction and implantation, both patients underwent complex diagnostic observations on days 7, 20, and 30 through objective, instrumental, and laboratory follow-up of inflammation using the Schiller–Pisarev test, laser Doppler flowmetry (LDF), and assessment of the level of pro-inflammatory cytokines interleukin 6 (IL-6) and tumor necrosis factor (TNF-α) and C-reactive protein (CRP). After tooth extraction on day 30, the clinical picture of both patients indicated complete subsidence of inflammation and stabilization of repair. The IL, CRP, and TNF-α levels were 1.36 and B. 1.75 pg/mL, 0.68 and 0.88 mg/L, and 17.8 and 21.3 pg/mL in patients A and B, respectively. LDF indicators were 18.47 conventional units in patient A, and the microcirculation parameter was 11.46 conventional units in patient B. Thirty days after implantation, the levels of IL-6, CRP, and TNF-α were 1.39 and 1.78 pg/mL, 0.74 and 0.92 mg/mL, and 18.9 and 20.2 pg/mL, respectively. The LDF values were 20.35 units in patient A, and the microcirculation parameter was 19.62 units in patient B. Comprehensive analysis of inflammation is necessary because of its high information content and ability to identify possible complications.