光照去同步模型下实验大鼠体能的季节性变化及其对体力活动的适应过程
- 作者: Gostuhina A.A.1,2, Zamoshina T.A.2,3, Svetlik M.V.2,3, Doroshenko O.S.1,3, Zhukova O.B.1, Zaitsev K.V.1
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隶属关系:
- Federal Scientific and Clinical Center of Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency of Russia
- Tomsk State University
- Siberian State Medical University
- 期: 卷 31, 编号 10 (2024)
- 页面: 738-749
- 栏目: ORIGINAL STUDY ARTICLES
- URL: https://journals.rcsi.science/1728-0869/article/view/314551
- DOI: https://doi.org/10.17816/humeco636704
- EDN: https://elibrary.ru/NNGVMW
- ID: 314551
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全文:
详细
论证。过去五年中,基于动物实验与流行病学观察的研究进一步证实了光照去同步对机体具有不利影响。生物节律结构的紊乱不可避免地导致体内稳态失衡和适应能力下降,进而可能诱发病理过程。
目的。探讨在光照去同步模型条件下实验大鼠体能的季节性动态及其对体力负荷的适应过程,并评估该条件下血清乳酸水平的变化情况。
材料与方法。实验在秋冬与春夏两季进行,研究对象为240只性成熟的Wistar雄性大鼠。通过将实验动物连续10天置于全天候强光(150 lx)或完全黑暗(2–3 lx)环境中,构建光照去同步模型。为研究体能的季节性变化,采用强迫游泳至完全疲劳的方法,在每天相同时间连续五天各进行一次测试。血清乳酸浓度使用标准试剂盒法测定。
结果。结果显示,大鼠体能水平与血清乳酸浓度存在显著相关性:体能越高,乳酸水平越低。同时,光照去同步联合游泳测试对乳酸水平的变化具有一定的特异性影响。
结论。在光照去同步条件下,实验大鼠体能的季节性节律及其血清乳酸含量的变化反映出机体适应-代偿机制处于紧张状态,并提示存在代谢失调的可能。
作者简介
Alena A. Gostuhina
Federal Scientific and Clinical Center of Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency of Russia; Tomsk State University
编辑信件的主要联系方式.
Email: antariks-tomsk2015@yandex.ru
ORCID iD: 0000-0003-3655-6505
SPIN 代码: 1036-5936
Cand. Sci. (Biology)
俄罗斯联邦, Moscow region, Solnechnogorsk; 1 Rosa Luxemburg st, Tomsk, 634009Tatyana A. Zamoshina
Tomsk State University; Siberian State Medical University
Email: limdff@yandex.ru
ORCID iD: 0000-0003-1868-9793
SPIN 代码: 7391-5386
Dr. Sci. (Biology), Professor
俄罗斯联邦, Tomsk; TomskMikhail V. Svetlik
Tomsk State University; Siberian State Medical University
Email: mihasv@mail.tsu.ru
ORCID iD: 0000-0003-0990-2580
SPIN 代码: 1863-7282
Cand. Sci. (Biology)
俄罗斯联邦, Tomsk; TomskOlga S. Doroshenko
Federal Scientific and Clinical Center of Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency of Russia; Siberian State Medical University
Email: doroshenko.olga.95@mail.ru
ORCID iD: 0000-0003-4764-4842
SPIN 代码: 4132-6216
俄罗斯联邦, Moscow region, Solnechnogorsk; Tomsk
Oksana B. Zhukova
Federal Scientific and Clinical Center of Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency of Russia
Email: limdff@yandex.ru
ORCID iD: 0000-0001-5016-7288
SPIN 代码: 5586-3475
MD, Dr. Sci. (Medicine)
俄罗斯联邦, Moscow region, SolnechnogorskKonstantin V. Zaitsev
Federal Scientific and Clinical Center of Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency of Russia
Email: limdff@yandex.ru
ORCID iD: 0000-0001-6504-5232
SPIN 代码: 5010-9381
MD, Cand. Sci. (Medicine)
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