Renin-angiotensin system gene polymorphism and aging
- Authors: Bebyakova N.A.1, Levitsky S.N.1, Shabalina I.A.1, Komandresova T.M.2, Kudryavtsev A.V.1
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Affiliations:
- Northern State Medical University
- Pskov State University
- Issue: Vol 30, No 8 (2023)
- Pages: 571-587
- Section: REVIEWS
- URL: https://journals.rcsi.science/1728-0869/article/view/252930
- DOI: https://doi.org/10.17816/humeco516580
- ID: 252930
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Abstract
A personalized healthy aging program, aimed at preservation of functional capacities in old ages, should consider genetic (hereditary) factors that determine the structure and functions of body organs and systems, and their age-related changes. Individual genetic characteristics of a person can influence the aging process. For this reason, recent research focuses on identifying genetic mechanisms of aging and longevity associated with multifactorial diseases. Renin-angiotensin system (RAS) contributes to the development of pathological conditions leading to cardiovascular diseases, cognitive changes, disorders of auditory and visual analyzers, and may determine the preservation of functional capacities in older adults. We present a literature review of the role of the RAS gene polymorphisms in the aging processes. The results of the synthesis of Russian and international literature indicated the contribution of polymorphic variants of the angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and angiotensin II receptor type 1 (AGTR1) genes to the development of pathological conditions and the associated decreases in functional capacities of an elderly person. Testing for these polymorphisms can be of a practical importance for personified health assessment and development of timely preventive interventions aimed at improving life expectancy and quality of life among older adults.
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##article.viewOnOriginalSite##About the authors
Natalia A. Bebyakova
Northern State Medical University
Email: nbebyakova@mail.ru
ORCID iD: 0000-0002-9346-1898
SPIN-code: 6326-5523
Dr. Sci. (Biol.), professor
Russian Federation, ArkhangelskSergey N. Levitsky
Northern State Medical University
Author for correspondence.
Email: sergeylevitski@yandex.ru
ORCID iD: 0000-0003-2588-620X
SPIN-code: 9846-7867
Cand. Sci. (Biol.), associate professor
Russian Federation, ArkhangelskIrina A. Shabalina
Northern State Medical University
Email: ira_sha@mail.ru
ORCID iD: 0000-0001-9425-3882
SPIN-code: 8015-5230
Cand. Sci. (Biol.), associate professor
Russian Federation, ArkhangelskTatyana M. Komandresova
Pskov State University
Email: tatmyh005@mail.ru
ORCID iD: 0000-0001-5317-7617
SPIN-code: 6792-8673
Cand. Sci. (Biol.), associate professor
Russian Federation, PskovAlexander V. Kudryavtsev
Northern State Medical University
Email: ispha09@gmail.com
ORCID iD: 0000-0001-8902-8947
SPIN-code: 9296-2930
PhD
Russian Federation, ArkhangelskReferences
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