Protein signaling molecules affecting the development of innate immunity mechanisms
- 作者: Moskalev A.1, Gumilevsky B.2, Apchel V.2,3, Tcygan V.2
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隶属关系:
- Military medical academy of S.M. Kirov
- Military Medical Academy of S.M. Kirov
- A.I. Herzen Russian State Pedagogical University of the Ministry of Education and Science of the Russian Federation
- 期: 卷 24, 编号 2 (2022)
- 页面: 353-362
- 栏目: Review
- URL: https://journals.rcsi.science/1682-7392/article/view/100441
- DOI: https://doi.org/10.17816/brmma100441
- ID: 100441
如何引用文章
详细
The principle protein molecules (interferon gene stimulator, adapter proteins, B-cell lymphoma 2 proteins, zinc-finger antiviral protein, and others), mechanisms of apoptosis, necroptosis, perforation of plasma membranes with kinase-like proteins of a mixed line, and ribonucleic acid neutralization, which ensure the development of innate immunity, are described. The main defense mechanisms that viruses have developed at the various stages of evolution are considered. The features of the development of the mechanisms of apoptosis and autophagy in a new coronavirus infection, which are associated with increased secretion of pro-inflammatory cytokines and chemokines, leading to severe damage to host cells, are given. It has been found that serum levels of several proteins formed during autophagy caused by SARS-CoV-2 can be used to predict disease severity. These include a protein associated with microtubules 1A/1B, a protein of sequestoma 1, and a protein of the cellular system of autophagy ― beclin-1. The multifaceted role of interferons in the inhibition of viral infection and the features of the violation of the activating functions of interferons in coronavirus infection are described.
作者简介
Alexander Moskalev
Military medical academy of S.M. Kirov
编辑信件的主要联系方式.
Email: alexmav195223@yandex.ru
ORCID iD: 0000-0002-3403-3850
SPIN 代码: 8227-2647
Doctor of Medical Sciences, Professor
俄罗斯联邦, Saint PetersburgBoris Gumilevsky
Military Medical Academy of S.M. Kirov
Email: 172602a@gmail.com
SPIN 代码: 3428-7704
Scopus 作者 ID: 6602391269
Researcher ID: J-1841-2017
Doctor of Medical Sciences, Professor
俄罗斯联邦, Saint PetersburgVasiliy Apchel
Military Medical Academy of S.M. Kirov; A.I. Herzen Russian State Pedagogical University of the Ministry of Education and Science of the Russian Federation
Email: apchelvya@mail.com
ORCID iD: 0000-0001-7658-4856
SPIN 代码: 4978-0785
Scopus 作者 ID: 6507529350
Researcher ID: Е-8190-2019
Doctor of Medical Sciences, Professor
俄罗斯联邦, Saint Petersburg; Saint PetersburgVasiliy Tcygan
Military Medical Academy of S.M. Kirov
Email: vn-t@mail.ru
ORCID iD: 0000-0003-1199-0911
SPIN 代码: 7215-6206
Doctor of Medical Sciences, Professor
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