The effectiveness of autologous mesenchymal stem cells in the treatment of liver cirrhosis and the method of their visualization in the patient’s body


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Abstract. The effectiveness of the influence of autologous mesenchymal stem cells on the function of liver tissue in liver cirrhosis of alimentary etiology is considered, as well as the possibility of visualization of the introduced cell structures with subsequent cytological confirmation. To be able to track autologous mesenchymal stem cells introduced in the patient’s body, they were labeled with iron oxide nanoparticles. Visualization of the introduced cell structures was performed using magnetic resonance imaging and ultrasound examination of the liver. 6 months after the cell therapy, clinical and biochemical blood tests, lidocaine test results, elastography indicators were evaluated, and the dynamics of hepatic encephalopathy was evaluated. The effectiveness of using autologous mesenchymal stem cells was evidenced by the improvement of the above indicators. Also, 6 months after treatment, a liver tissue biopsy was performed from the sites of fixation of previously introduced cell structures. Histological examination revealed the largest number of labeled cells in the liver micro-nodes, as well as at the borders of micro-nodes and fibrous septa. The use of cell therapy in a patient suffering from liver cirrhosis of alimentary etiology helped to improve the indicators of laboratory and instrumental research methods. No complications were detected during the procedure.

作者简介

I. Kotkas

North-Western State Medical University named after I.I. Mechnikov

编辑信件的主要联系方式.
Email: inna.kotkas@yandex.ru
俄罗斯联邦, Saint Petersburg

N. Enukashvili

North-Western State Medical University named after I.I. Mechnikov; Institute of Cytology of the Russian Academy of Sciences

Email: inna.kotkas@yandex.ru
俄罗斯联邦, Saint Petersburg; Saint Petersburg

Sh. Asadulayev

North-Western State Medical University named after I.I. Mechnikov

Email: inna.kotkas@yandex.ru
俄罗斯联邦, Saint Petersburg

A. Chubar’

Institute of Cytology of the Russian Academy of Sciences

Email: inna.kotkas@yandex.ru
俄罗斯联邦, Saint Petersburg

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