PROBLEMS OF PREVENTION OF SUDDEN CARDIAC DEATH IN ARMED FORCES OF THE RUSSIAN FEDERATION


Cite item

Full Text

Abstract

Currently, in connection with the development of methods for genetic studies, increased attention to the problem of sudden death and its prevention. The majority of stops cardiac activity occur without prior symptoms and is almost always fatal despite resuscitation. At a young age cause of sudden cardiac death often remains unclear even after autopsy, because some diseases, such as channelopathies, or drug-arrhythmia, not associated with any structural changes of the cardiovascular system and result in death in this age group. In recent years, technological progress in the field of genetics has facilitated the study of a large number of genes, which allowed to map several key genes with the reasons for the development of sudden cardiac death, which may allow the stratification of risk in young individuals based on the genetic data (2 figs, bibliography: 38 refs).

About the authors

Vadim V Tyrenko

S. M. Kirov Military Medical Academy the Russian Defense Ministry

Yu V Ovchinnikov

S. M. Kirov Military Medical Academy the Russian Defense Ministry

Sergei G Bologov

S. M. Kirov Military Medical Academy the Russian Defense Ministry

Sergey B Ignatev

S. M. Kirov Military Medical Academy the Russian Defense Ministry

Vasiliy A Kachnov

S. M. Kirov Military Medical Academy the Russian Defense Ministry

Andrey V Koltsov

S. M. Kirov Military Medical Academy the Russian Defense Ministry

References

  1. Шляхто Е. В., Арутюнов Г. П., Беленков Ю. Н., Ардашев А. В. Национальные рекомендации по определению риска и профилактике внезапной сердечной смерти. Архивъ внутренней медицины. 2013; 4: 5-15.
  2. Silvia P. G., Blomström-Lundqvist C., Mazzanti A., Bloma N., Borggrefe M., Camm J., Elliott P., Fitzsimons D., Hatala R., Hindricks G., Kirchhof P., Kjeldsen K., Kuck K., Hernandez A., Nikolaou N., Norekvål T., Spaulding C., Veldhuisen D. Рекомендации ESC по лечению пациентов с желудочковыми нарушениями ритма и профилактике внезапной сердечной смерти 2015. Российский кардиологический журнал. 2016; 7: 5-86). doi: 10.15829/1560-4071-2016-7-5-86
  3. Campuzano O., Allegue C., Partemi S., Iglesias A., Oliva A., Brugada R. Negative autopsy and sudden cardiac death. Int. J. Leg. Med. 2014; 128: 599-606.
  4. Eckart R. E., Shry E. A., Burke A. P., McNear J. A., Appel D. A., Castillo-Rojas L. M., Avedissian L., Pearse L. A., Potter R. N., Tremaine L., Gentlesk P. J., Huffer L., Reich S. S., Stevenson W. G. Sudden death in young adults: An autopsy-based series of a population undergoing active surveillance. J. Am. Coll. Cardiol. 2011; 58: 1254-61.
  5. Mazzanti A., O’Rourke S., Ng K., Miceli C., Borio G., Curcio A., Esposito F., Napolitano C., Priori S. G. The usual suspects in sudden cardiac death of the young: A focus on inherited arrhythmogenic diseases. Expert Rev. Cardiovasc. Ther. 2014; 12: 499-519.
  6. Boczek N. J., Tester D. J., Ackerman M. J. The molecular autopsy: An indispensable step following sudden cardiac death in the young? Herzschrittmacherther. Elektrophysiol. 2012. 23: 167-73.
  7. The ARIC Investigators. The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. Am. J. Epidemiol. 1989; 129: 687-702.
  8. Deo R., Norby F. L., Katz R., Sotoodehnia N., Adabag S., DeFilippi C. R., Kestenbaum B., Chen L. Y., Heckbert S. R., Folsom A. R., Kronmal R. A., Konety S., Patton K. K., Siscovick D., Shlipak M. G., Alonso A. Development and Validation of a Sudden Cardiac Death Prediction Model for the General Population. Circulation. 2016; 134 (11): 806-16.
  9. Fried L. P., Borhani N. O., Enright P., Furberg C. D., Gardin J. M., Kronmal R. A., Kuller L. H., Manolio T. A., Mittelmark M. B., Newman A., O'Leary D. H., Psaty B., Rautaharju P., Tracy R. P., Weiler P. G. The Cardiovascular Health Study: design and rationale. Ann. Epidemiol. 1991; 1: 263-76.
  10. Kaufman E. S. Arrhythmic risk in congenital long QT syndrome. J. Electrocardiol. 2011; 44: 645-9.
  11. Schwartz P. J., Moss A. J., Vincent G. M., Crampton R. S. Diagnostic criteria for the long QT syndrome. An update. Circulation. 1993; 88: 782-4.
  12. Romano C., Gemme G., Pongiglione R. Rare cardiac arrythmias of the pediatric age. II. Syncopal attacks due to paroxysmal ventricular fibrillation (presentation of 1st case in Italian pediatric literature). Clin. Pediatr. 1963; 45: 656-83.
  13. Ward O. C. A new familial cardiac syndrome in children. J. Ir. Med. Assoc. 1964; 54: 103-6.
  14. Jervell A., Lange-Nielsen F. Congenital deaf-mutism, functional heart disease with prolongation of the QT interval and sudden death. Am. Heart J. 1957; 54: 59-68.
  15. Levine S. A., Woodworth C. R. Congenital deaf-mutism, prolonged QT interval, syncopal attacks and sudden death. N. Engl. J. Med. 1958; 259: 412-7.
  16. Curran M. E., Splawski I., Timothy K. W., Vincent G. M., Green E. D., Keating M. T. A molecular basis for cardiac arrhythmia: Herg mutations cause long QT syndrome. Cell. 1995; 80: 795-803.
  17. Mohler P. J., Schott J. J., Gramolini A. O., Dilly K. W., Guatimosim S., duBell W. H., Song L. S., Haurogné K., Kyndt F., Ali M. E., Rogers T. B., Lederer W. J., Escande D., Le Marec H., Bennett V. Ankyrin-b mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature. 2003; 421: 634-9.
  18. Vatta M., Ackerman M. J., Ye B., Makielski J. C., Ughanze E. E., Taylor E. W., Tester D. J., Balijepalli R. C., Foell J. D., Li Z., Kamp T. J., Towbin J. A. Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome. Circulation. 2006; 114: 2104-12.
  19. Wang Q., Shen J., Splawski I., Atkinson D., Li Z., Robinson J. L., Moss A. J., Towbin J. A., Keating M. T. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell. 1995; 80: 805-11.
  20. Gaita F., Giustetto C., Bianchi F., Wolpert C., Schimpf R., Riccardi R., Grossi S., Richiardi E., Borggrefe M. Short QT syndrome: A familial cause of sudden death. Circulation. 2003; 108: 965-70.
  21. Gollob M. H., Redpath C. J., Roberts J. D. The short QT syndrome: Proposed diagnostic criteria. J. Am. Coll. Cardiol. 2011; 57: 802-12.
  22. Gussak I., Brugada P., Brugada J., Wright R. S., Kopecky S. L., Chaitman B. R., Bjerregaard P. Idiopathic short QT interval: A new clinical syndrome? Cardiology. 2000; 94: 99-102.
  23. Holbrook M., Malik M., Shah R. R., Valentin J.-P. Drug induced shortening of the QT/QTC interval: An emerging safety issue warranting further modelling and evaluation in drug research and development? J. Pharmacol. Toxicol. Methods. 2009; 59: 21-8.
  24. Bellocq C., van Ginneken A. C., Bezzina C. R., Alders M., Escande D., Mannens M. M., Baró I., Wilde A. A. Mutation in the KCNQ1 gene leading to the short QT-interval syndrome. Circulation. 2004; 109: 2394-7.
  25. Templin C., Ghadri J. R., Rougier J. S., Baumer A., Kaplan V., Albesa M., Sticht H., Rauch A., Puleo C., Hu D., Barajas-Martinez H., Antzelevitch C., Lüscher T. F., Abriel H., Duru F. Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6). Eur. Heart J. 2011; 32: 1077-88.
  26. Berne P., Brugada J. Brugada syndrome 2012. Circ. J. 2012; 76: 1563-71.
  27. Brugada R., Campuzano O., Sarquella-Brugada G., Brugada J., Brugada P. Brugada syndrome. Methodist Debakey Cardiovasc. J. 2014; 10: 25-8.
  28. Shy D., Gillet L., Abriel H. Cardiac sodium channel NaV1.5 distribution in myocytes via interacting proteins: The multiple pool model. Biochim. Biophys. Acta. 2013; 1833: 886-94.
  29. Kattygnarath D., Maugenre S., Neyroud N., Balse E., Ichai C., Denjoy I., Dilanian G., Martins R. P., Fressart V., Berthet M., Schott J. J., Leenhardt A., Probst V., Le Marec H., Hainque B., Coulombe A., Hatem S. N., Guicheney P. MOG1: A new susceptibility gene for Brugada syndrome. Circ. Cardiovasc. Genet. 2011; 4: 261-8.
  30. Burashnikov E., Pfeiffer R., Barajas-Martinez H., Delpón E., Hu D., Desai M., Borggrefe M., Häissaguerre M., Kanter R., Pollevick G. D., Guerchicoff A., Laiño R., Marieb M., Nademanee K., Nam G. B., Robles R., Schimpf R., Stapleton D. D., Viskin S., Winters S., Wolpert C., Zimmern S., Veltmann C., Antzelevitch C. Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death. Heart Rhythm. 2010; 7: 1872-82.
  31. Brugada R., Hong K., Dumaine R., Cordeiro J., Gaita F., Borggrefe M., Menendez T. M., Brugada J., Pollevick G. D., Wolpert C., Burashnikov E., Matsuo K., Wu Y. S., Guerchicoff A., Bianchi F., Giustetto C., Schimpf R., Brugada P., Antzelevitch C. Sudden death associated with short-QT syndrome linked to mutations in HERG. Circulation. 2004; 109: 30-5.
  32. Hu D., Barajas-Martinez H., Pfeiffer R., Dezi F., Pfeiffer J., Buch T., Betzenhauser M. J., Belardinelli L., Kahlig K. M., Rajamani S., DeAntonio H. J., Myerburg R. J., Ito H., Deshmukh P., Marieb M., Nam G. B., Bhatia A., Hasdemir C., Haïssaguerre M., Veltmann C., Schimpf R., Borggrefe M., Viskin S., Antzelevitch C. Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome. J. Am. Coll. Cardiol. 2014; 64: 66-79.
  33. Postma A. V., Denjoy I., Hoorntje T. M., Lupoglazoff J. M., Da Costa A., Sebillon P., Mannens M. M., Wilde A. A., Guicheney P. Absence of calsequestrin 2 causes severe forms of catecholaminergic polymorphic ventricular tachycardia. Circ. Res. 2002; 91: 21-6.
  34. Priori S. G., Napolitano C., Tiso N., Memmi M., Vignati G., Bloise R., Sorrentino V., Danieli G. A. Mutations in the cardiac ryanodine receptor gene (HRYR2) underlie catecholaminergic polymorphic ventricular tachycardia. Circulation. 2001; 103: 196-200.
  35. Sumitomo N. Current topics in catecholaminergic polymorphic ventricular tachycardia. J. Arrhythm. 2016; 32: 344-51.
  36. Chen Q., Kirsch G. E., Zhang D., Brugada R., Brugada J., Brugada P., Potenza D., Moya A., Borggrefe M., Breithardt G., Ortiz-Lopez R., Wang Z., Antzelevitch C., O'Brien R. E., Schulze-Bahr E., Keating M. T., Towbin J. A., Wang Q. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature. 1998; 392: 293-6.
  37. Fernández-Falgueras A., Sarquella-Brugada G., Brugada J., Brugada R., Campuzano O. Cardiac Channelopathies and Sudden Death: Recent Clinical and Genetic Advances. Biology. 2017; 6 (1): 7.
  38. Makita N., Yagihara N., Crotti L., Johnson C. N., Beckmann B. M., Roh M. S., Shigemizu D., Lichtner P., Ishikawa T., Aiba T., Homfray T., Behr E. R., Klug D., Denjoy I., Mastantuono E., Theisen D., Tsunoda T., Satake W., Toda T., Nakagawa H., Tsuji Y., Tsuchiya T., Yamamoto H., Miyamoto Y., Endo N., Kimura A., Ozaki K., Motomura H., Suda K., Tanaka T., Schwartz P. J., Meitinger T., Kääb S., Guicheney P., Shimizu W., Bhuiyan Z. A., Watanabe H., Chazin W. J., George A. L. Jr. Novel calmodulin mutations associated with congenital arrhythmia susceptibility. Circ. Cardiovasc. Genet. 2014; 7: 466-74.

Copyright (c) 2017 Tyrenko V.V., Ovchinnikov Y.V., Bologov S.G., Ignatev S.B., Kachnov V.A., Koltsov A.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies