Evaluation of vaccine "Sputnik V” immunogenicity and reactogenicity when it is used in military personnel

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Abstract

The article presents the results of a study of the immunogenicity and reactogenicity of the vaccine Gam-COVID-Vac (Sputnik V) when used in military personnel undergoing military service on conscription. From 300 military personnel consistently vaccinated with one and two components of Gam-COVID-Vac at the intervals of 21 days, blood serum was obtained and examined three times: before vaccination, and 30 and 60 days after the introduction of the first component of the vaccine. In the blood serums, the content of Class G antibodies to the SARS-CoV-2 was determined by the method of solid-phase enzyme immunoassay. After immunization with the Gam-COVID-Vac vaccine, the average geometric titer of Class G antibodies to SARS-CoV-2 -in the blood serum of a military personnel obtained during the second and third examinations (5.02 log2 and 5.67 log2) increased by 2.4 and 2.7 times, respectively (p < 0.05), compared to the same indicator before the vaccination (2.11 log2). Total of 30 days after the introduction of the first component of the vaccine (Nine days after the introduction of the second component of the vaccine), Class G antibodies to the new coronavirus SARS-CoV-2 were detected in the 86.7% of military personnel, and after 60 days — in 92% of vaccinated. Studies have revealed moderate reactogenicity of the vaccine. Moreover, the proportion of postvaccination reactions in the first 3–5 days after the introduction of the second component of the vaccine was less after the introduction of the first component of the vaccine. So, if after the introduction of the first component of the vaccine, an increase in body temperature > 37 °C was observed in 20% of military personnel, then after the introduction of the second component only in 9%, and the share of local reactions decreased from 9−4%. There have been no cases of serious adverse events after immunization of military personnel with the Gam-COVID-Vac vaccine.

About the authors

Sergey D. Zhogolev

Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation

Author for correspondence.
Email: SZhogolev@rambler.ru
SPIN-code: 7667-5729

doctor of medical sciences, professor

Russian Federation, Saint Petersburg

Alexey N. Gorenchuk

Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation

Email: 3312600@bk.ru
SPIN-code: 7755-3261

associate professor

Russian Federation, Saint Petersburg

Alexander A. Kuzin

Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation

Email: paster-spb@mail.ru
SPIN-code: 6220-1218

doctor of medical sciences, associate professor

Russian Federation, Saint Petersburg

Pavel V. Kulikov

Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation

Email: kpvsel@mail.ru
ORCID iD: 0000-0002-6623-9474
SPIN-code: 7920-4582

lecturer

Russian Federation, Saint Petersburg

Konstantin D. Zhogolev

Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation

Email: kjogolev@rambler.ru
SPIN-code: 8445-2245

doctor of medical sciences, associate professor

Russian Federation, Saint Petersburg

Vasiliy Ya. Apchel

Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation; A.I. Herzen Russian State Pedagogical University of the Ministry of Education and Science of the Russian Federation

Email: SZhogolev@rambler.ru
ORCID iD: 0000-0001-7658-4856
SPIN-code: 4978-0785
Scopus Author ID: 6507529350
ResearcherId: Е-8190-2019

doctor of medical sciences, professor

Russian Federation, Saint Petersburg; Saint Petersburg

Timofey S. Sergeev

985 Center for State Sanitary and Epidemiological Supervision Ministry of Defense of Russia

Email: timofey.sergeev.s@gmail.com

bacteriologist

Russian Federation, Saint Petersburg

Evgeny V. Lantsov

Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation

Email: lantsov83@mail.ru
SPIN-code: 4384-2924

candidate of medical sciences

Russian Federation, Saint Petersburg

Sergey V. Artebyakin

Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation

Email: asvdoc@rambler.ru
SPIN-code: 5536-5620

associate professor
Russian Federation, Saint Petersburg

Denis A. Zharkov

Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation

Email: jardenmed@mail.ru
SPIN-code: 5330-1690

candidate of medical sciences

Russian Federation, Saint Petersburg

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2. Fig. 1. Distribution of a military personnel in the group of vaccinated by the content of antibody titers against COVID-19

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3. Fig. 2. Average geometric titers of the antibodies against COVID-19 in the blood sera of military personnel before and after the vaccination (log2)

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4. Fig. 3. Dynamics of the structure of the level of antibodies to SARS-CoV-2 in vaccinated military personnel

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Copyright (c) 2021 Zhogolev S.D., Gorenchuk A.N., Kuzin A.A., Kulikov P.V., Zhogolev K.D., Apchel V.Y., Sergeev T.S., Lantsov E.V., Artebyakin S.V., Zharkov D.A.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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