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Evaluation of vaccine "Sputnik V” immunogenicity and reactogenicity when it is used in military personnel
- 作者: Zhogolev S.1, Gorenchuk A.1, Kuzin A.1, Kulikov P.1, Zhogolev K.1, Apchel V.1,2, Sergeev T.3, Lantsov E.1, Artebyakin S.1, Zharkov D.1
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隶属关系:
- Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
- A.I. Herzen Russian State Pedagogical University of the Ministry of Education and Science of the Russian Federation
- 985 Center for State Sanitary and Epidemiological Supervision Ministry of Defense of Russia
- 期: 卷 23, 编号 4 (2021)
- 页面: 147-152
- 栏目: Clinical trials
- URL: https://journals.rcsi.science/1682-7392/article/view/80760
- DOI: https://doi.org/10.17816/brmma80760
- ID: 80760
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详细
The article presents the results of a study of the immunogenicity and reactogenicity of the vaccine Gam-COVID-Vac (Sputnik V) when used in military personnel undergoing military service on conscription. From 300 military personnel consistently vaccinated with one and two components of Gam-COVID-Vac at the intervals of 21 days, blood serum was obtained and examined three times: before vaccination, and 30 and 60 days after the introduction of the first component of the vaccine. In the blood serums, the content of Class G antibodies to the SARS-CoV-2 was determined by the method of solid-phase enzyme immunoassay. After immunization with the Gam-COVID-Vac vaccine, the average geometric titer of Class G antibodies to SARS-CoV-2 -in the blood serum of a military personnel obtained during the second and third examinations (5.02 log2 and 5.67 log2) increased by 2.4 and 2.7 times, respectively (p < 0.05), compared to the same indicator before the vaccination (2.11 log2). Total of 30 days after the introduction of the first component of the vaccine (Nine days after the introduction of the second component of the vaccine), Class G antibodies to the new coronavirus SARS-CoV-2 were detected in the 86.7% of military personnel, and after 60 days — in 92% of vaccinated. Studies have revealed moderate reactogenicity of the vaccine. Moreover, the proportion of postvaccination reactions in the first 3–5 days after the introduction of the second component of the vaccine was less after the introduction of the first component of the vaccine. So, if after the introduction of the first component of the vaccine, an increase in body temperature > 37 °C was observed in 20% of military personnel, then after the introduction of the second component only in 9%, and the share of local reactions decreased from 9−4%. There have been no cases of serious adverse events after immunization of military personnel with the Gam-COVID-Vac vaccine.
作者简介
Sergey Zhogolev
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
编辑信件的主要联系方式.
Email: SZhogolev@rambler.ru
SPIN 代码: 7667-5729
doctor of medical sciences, professor
俄罗斯联邦, Saint PetersburgAlexey Gorenchuk
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
Email: 3312600@bk.ru
SPIN 代码: 7755-3261
associate professor
俄罗斯联邦, Saint PetersburgAlexander Kuzin
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
Email: paster-spb@mail.ru
SPIN 代码: 6220-1218
doctor of medical sciences, associate professor
俄罗斯联邦, Saint PetersburgPavel Kulikov
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
Email: kpvsel@mail.ru
ORCID iD: 0000-0002-6623-9474
SPIN 代码: 7920-4582
lecturer
俄罗斯联邦, Saint PetersburgKonstantin Zhogolev
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
Email: kjogolev@rambler.ru
SPIN 代码: 8445-2245
doctor of medical sciences, associate professor
俄罗斯联邦, Saint PetersburgVasiliy Apchel
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation; A.I. Herzen Russian State Pedagogical University of the Ministry of Education and Science of the Russian Federation
Email: SZhogolev@rambler.ru
ORCID iD: 0000-0001-7658-4856
SPIN 代码: 4978-0785
Scopus 作者 ID: 6507529350
Researcher ID: Е-8190-2019
doctor of medical sciences, professor
俄罗斯联邦, Saint Petersburg; Saint PetersburgTimofey Sergeev
985 Center for State Sanitary and Epidemiological Supervision Ministry of Defense of Russia
Email: timofey.sergeev.s@gmail.com
bacteriologist
俄罗斯联邦, Saint PetersburgEvgeny Lantsov
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
Email: lantsov83@mail.ru
SPIN 代码: 4384-2924
candidate of medical sciences
俄罗斯联邦, Saint PetersburgSergey Artebyakin
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
Email: asvdoc@rambler.ru
SPIN 代码: 5536-5620
associate professor俄罗斯联邦, Saint Petersburg
Denis Zharkov
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
Email: jardenmed@mail.ru
SPIN 代码: 5330-1690
candidate of medical sciences
俄罗斯联邦, Saint Petersburg参考
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