Email this article 
Programmed extracorporeal photochemotherapy in the complex treatment of systemic scleroderma
- Authors: Manuilov A.S.1, Belskih A.N.1, Bardakov S.N.1, Apchel A.V.1,2, Tishko V.V.1, Zakharov M.V.1, Sokolov A.A.1, Ryabova T.S.1, Volkov K.Y.1, Vasylieva I.А.3
-
Affiliations:
- Military medical academy of S.M. Kirov
- Первый государственный медицинский университет им. академика И.П. Павлова
- Issue: Vol 22, No 4 (2020)
- Pages: 28-32
- Section: Clinical trials
- URL: https://journals.rcsi.science/1682-7392/article/view/62800
- DOI: https://doi.org/10.17816/brmma62800
- ID: 62800
Cite item
Open Access
Access granted
Subscription Access
Abstract
The choice of non-drug methods for the treatment of systemic scleroderma is currently very limited. Several studies show that extracorporeal photochemotherapy can improve kidney and lung function and reduce skin fibrosis in patients with systemic scleroderma. We studied the dynamics of clinical and laboratory parameters in patients with systemic scleroderma with an assessment before and after 12 months against the background of complex treatment, which included programmed extracorporeal photochemotherapy. Indications for inclusion in the study was the ineffectiveness of standard therapy with glucocorticoids and cytostatics or the impossibility of their use, as well as signs of an unfavorable prognosis of the disease: diffuse form, high skin count (>14), rapid progression with a significant initial decrease in the glomerular filtration rate, forced vital capacity, high immunological activity (high titer of antinuclear factor and positivity for antibodies to Scl-70). When evaluating the results of complex treatment, a good clinical effect was observed in all patients: the induration of the skin decreased, the functionality of the lungs and kidneys increased. A significant decrease in the disease activity index was noted. These positive changes were the basis for a decrease in the daily dose of glucocorticoids. Significantly significant changes were observed in a decrease in the immunological activity of the disease: levels of C-reactive protein, erythrocyte sedimentation rate and immunoglobulin G, antinuclear factor titer and all types of circulating immune complexes. The results of our study confirm the data of other studies that demonstrated the positive effect of extracorporeal photochemotherapy as a component of the complex treatment of systemic scleroderma.
Full Text
##article.viewOnOriginalSite##About the authors
A. S. Manuilov
Military medical academy of S.M. Kirov
Author for correspondence.
Email: vmeda-nio@mil.ru
Russian Federation, Saint Petersburg
A. N. Belskih
Military medical academy of S.M. Kirov
Email: vmeda-nio@mil.ru
Russian Federation, Saint Petersburg
S. N. Bardakov
Military medical academy of S.M. Kirov
Email: vmeda-nio@mil.ru
Russian Federation, Saint Petersburg
A. V. Apchel
Military medical academy of S.M. Kirov;
Email: vmeda-nio@mil.ru
Russian Federation, Saint Petersburg
V. V. Tishko
Military medical academy of S.M. Kirov
Email: vmeda-nio@mil.ru
Russian Federation, Saint Petersburg
M. V. Zakharov
Military medical academy of S.M. Kirov
Email: vmeda-nio@mil.ru
Russian Federation, Saint Petersburg
A. A. Sokolov
Military medical academy of S.M. Kirov
Email: vmeda-nio@mil.ru
Russian Federation, Saint Petersburg
T. S. Ryabova
Military medical academy of S.M. Kirov
Email: vmeda-nio@mil.ru
Russian Federation, Saint Petersburg
K. Yu. Volkov
Military medical academy of S.M. Kirov
Email: vmeda-nio@mil.ru
Russian Federation, Saint Petersburg
I. А. Vasylieva
Первый государственный медицинский университет им. академика И.П. Павлова
Email: vmeda-nio@mil.ru
Russian Federation, Санкт-Петербург
References
Supplementary files
