Program extracorporeal photophoresis in complex treatment of psoriatic arthritis


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Abstract

The results of complex treatment with the programmed procedures of extracorporeal photopheresis and methotrexate in patients with psoriatic arthritis for 12 months are presented. It has been established that program extracorporeal photopheresis in combination with basic therapy with methotrexate in patients with psoriatic arthritis have a significant effect on the relief of articular syndrome (reduction of morning stiffness, pain intensity, joint swelling). It was revealed that the inclusion of programmed extracorporeal photopheresis and methotrexate in the complex treatment of psoriatic arthritis reduces the level of circulating low molecular weight, medium molecular weight and high molecular weight immune complexes and in most cases leads to clinical and immunological remission. This is confirmed by a decrease in complaints of the severity of articular syndrome and a decrease in the clinical and laboratory activity of the disease (a significant decrease in the level of C-reactive protein, erythrocyte sedimentation rate). A scheme has been developed for the programmed use of extracorporeal photopheresis procedures in the complex treatment of psoriatic arthritis, which consists of 2 procedures every other day with an interval of 2,5-3 months for 12 months. Combined therapy with the programmed application of extracorporeal photopheresis procedures and methotrexate prolongs the period of disease remission and can be recommended for patients with psoriatic arthritis with high activity, insufficient effect of basic therapy and intolerance to higher doses of immunosuppressive drugs.

About the authors

A S Manuilov

Военно-медицинская академия им. С.М. Кирова

Email: vmeda-nio@mil.ru

A N Belskykh

Военно-медицинская академия им. С.М. Кирова

Email: vmeda-nio@mil.ru

S N Bardakov

Военно-медицинская академия им. С.М. Кирова

Email: vmeda-nio@mil.ru

A V Apchel

Военно-медицинская академия им. С.М. Кирова Северо-Западный медицинский учебный центр последипломного образования

Email: vmeda-nio@mil.ru

V V Tishko

Военно-медицинская академия им. С.М. Кирова

Email: vmeda-nio@mil.ru

M V Zakharov

Военно-медицинская академия им. С.М. Кирова

Email: vmeda-nio@mil.ru

A A Sokolov

Военно-медицинская академия им. С.М. Кирова

Email: vmeda-nio@mil.ru

T S Ryabova

Военно-медицинская академия им. С.М. Кирова

Email: vmeda-nio@mil.ru

E V Sherbakov

Военно-медицинская академия им. С.М. Кирова

Email: vmeda-nio@mil.ru

K Yu Volkov

Военно-медицинская академия им. С.М. Кирова

Email: vmeda-nio@mil.ru

I V Kudryavtsev

Военно-медицинская академия им. С.М. Кирова Институт экспериментальной медицины Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова

Email: vmeda-nio@mil.ru

M K Serebriakova

Военно-медицинская академия им. С.М. Кирова Институт экспериментальной медицины

Email: vmeda-nio@mil.ru

A S Trulev

Военно-медицинская академия им. С.М. Кирова Институт экспериментальной медицины

Email: vmeda-nio@mil.ru

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Copyright (c) 2020 Manuilov A.S., Belskykh A.N., Bardakov S.N., Apchel A.V., Tishko V.V., Zakharov M.V., Sokolov A.A., Ryabova T.S., Sherbakov E.V., Volkov K.Y., Kudryavtsev I.V., Serebriakova M.K., Trulev A.S.

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