Metabolic status, ultrasound changes of liver and vascular artery wall in men with abdominal obesity

The prevalence of metabolic, vascular and hepatic disorders in young and middle-aged men suffering from abdominal obesity was estimated. It was found that in men suffering from initial obesity, compared with patients with normal diet, a high frequency of arterial hypertension (67 and 37%, χ2=41,5; p <0,001), atherogenic dyslipidemia (59 and34%, χ2=26; p<0,001), prediabetes (47 and 17%; p<0,001), atherosclerosis of the common carotid arteries (26 and 15%, χ2=8,2; p=0,004) and non-alcoholic fatty liver disease (27 and 6%, χ2=124; p <0,001). In obesity, a moderately elevated concentration of leptin (p<0,001), tumor necrosis factor α (p=0,005) and ghrelin (p=0,009) were detected. Patients with a body mass index >30 kg/m2 showed signs of remodeling of the left heart chambers in the form of an increase in the volume of the left atrium and left ventricular hypertrophy (p<0,001). The arterial stiffness indices as a whole in the sample and in the groups were within normal values without intragroup differences (p>0,05). A significant correlation between obesity and prediabetes, dyslipidemia and dysglycemia, hypertrophy of the left heart chambers, and stage of hepatic fibrosis was revealed. Against the background of initial obesity, an adipokine and carbohydrate-lipid imbalance is determined, which contributes to the development of insulin resistance, chronic aseptic inflammation and endothelial dysfunction. The presence of non- alcoholic fatty liver disease in combination with its fibrosis in this category of patients should be considered an early marker of metabolic syndrome and atherosclerosis.

metabolic syndrome, subclinical atherosclerosis, dyslipidemia, arterial hypertension, endothelial dysfunction, prediabetes, nonalcoholic fatty liver disease, young and middle-aged men