SHORT-TERM OUTCOMES OF SURGICAL TREATMENT OF PANCREATIC NEUROENDOCRINE TUMORS ASSOCIATED WITH THE SYNDROME OF MULTIPLEENDOCRINE NEOPLASIA TYPE 1

Background: pancreaticneuroendocrine tumors occur in almost all patients with multiple endocrine neoplasia type 1 (MEN1) and are a major cause of death. Surgical resection is the only potentially curative therapy for pNETs, otherwise various endocrine syndromesdevelop threatening the patient's life. Aim: to evaluate the short-term results of surgical management of patients with pancreatic neuroendocrine tumors with MEN1. Materials and methods: by last 20 years, 40 patients with pancreatic neuroendocrine tumors within MEN1 were operated. Results: in the early postoperative period,according to the classification of Clavien-Dindo, complications occurred in 12 (26%) patients. The following types of complications were diagnosed: IIIa in 6 patients; IIIb - in 2; type V in 4 patients. Complications of types I, II and IV were not identified. Conclusion: less percentage of postoperative complications is achieved by performing organ-preserving operations, after precise imaging diagnose, due to minimal intraoperative pancreatic injury.

pancreatic neuroendocrine tumors, multiple endocrine neoplasia type 1, surgical treatment, short-term results