SHORT-TERM OUTCOMES OF SURGICAL TREATMENT OF PANCREATIC NEUROENDOCRINE TUMORS ASSOCIATED WITH THE SYNDROME OF MULTIPLEENDOCRINE NEOPLASIA TYPE 1
- 作者: Egorov A1, Vasilyev I1, Ivashov I1, Thakur A1
-
隶属关系:
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- 期: 卷 21, 编号 1 (2019)
- 页面: 72-75
- 栏目: Articles
- URL: https://journals.rcsi.science/1682-7392/article/view/13049
- DOI: https://doi.org/10.17816/brmma13049
- ID: 13049
如何引用文章
全文:
详细
Background: pancreaticneuroendocrine tumors occur in almost all patients with multiple endocrine neoplasia type 1 (MEN1) and are a major cause of death. Surgical resection is the only potentially curative therapy for pNETs, otherwise various endocrine syndromesdevelop threatening the patient's life. Aim: to evaluate the short-term results of surgical management of patients with pancreatic neuroendocrine tumors with MEN1. Materials and methods: by last 20 years, 40 patients with pancreatic neuroendocrine tumors within MEN1 were operated. Results: in the early postoperative period,according to the classification of Clavien-Dindo, complications occurred in 12 (26%) patients. The following types of complications were diagnosed: IIIa in 6 patients; IIIb - in 2; type V in 4 patients. Complications of types I, II and IV were not identified. Conclusion: less percentage of postoperative complications is achieved by performing organ-preserving operations, after precise imaging diagnose, due to minimal intraoperative pancreatic injury.
作者简介
A Egorov
I.M. Sechenov First Moscow State Medical University (Sechenov University)119991Trubetskaya str., 8, p. 2, Moscow, Russia
I Vasilyev
I.M. Sechenov First Moscow State Medical University (Sechenov University)119991Trubetskaya str., 8, p. 2, Moscow, Russia
I Ivashov
I.M. Sechenov First Moscow State Medical University (Sechenov University)119991Trubetskaya str., 8, p. 2, Moscow, Russia
A Thakur
I.M. Sechenov First Moscow State Medical University (Sechenov University)119991Trubetskaya str., 8, p. 2, Moscow, Russia
参考
- Crippa S., Zerbi A., Boninsegna L. et al. Surgical Management of Insulinomas: Short- and Long-term Outcomes After Enucleations and Pancreatic Resections. //Arch. Surg. - 2012. - Vol.147, №3. -P. 261-266.
- Calender, A.; Cadiot, G.; Mignon M. Multiple endocrine neoplasia type 1: Genetic and clinical aspects. Gastroenterol. Clin. Biol. 2001, 25, 38-48.
- Chanson, P.; Cadiot, G.; Murat, A. Management of patients and subjects at risk for multiple endocrine neoplasia type 1: MEN 1. GENEM 1. Grouped’Etude des NéoplasiesEndocriniennes Multiples de type 1. Horm. Res. 1997, 47, 211-220.
- Franko J, Feng W, Yip L, Genovese E and Moser AJ: Non-functional neuroendocrine carcinoma of the pancreas: Incidence, tumor biology, and outcomes in 2,158 patients. J GastrointestSurg 14: 541-548, 2010.
- Niina Y, Fujimori N, Nakamura T, et al. The current strategy for managing pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1. Gut Liver 2012;6:287-94.
- Егоров А.В., Мусаев Г.Х., Кондрашин С.А. и соавт. Диагностика и лечениебольныхнейроэндокриннымиопухолямиподжелудочнойжелезыприсиндромемножественнойэндокриннойнеоплазии 1го типа // Анналыхирургическойгепатологии. - 2010. - Т.15, №3. -С. 25-30.
- Kimura W., Tezuka K., Hirai I. Surgical management of pancreatic neuroendocrine tumors. // Surg. Today. - 2011. - Vol.41, №10. -P. 1332-1343.
![](/img/style/loading.gif)