AUTOIMMUNOLOGY: NEW BRANCH OF MEDICINE


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Abstract

The article written by the co-chairmen of the First St. Petersburg Congress on Autoimmunity "Bridge between East and West", held in St. Petersburg State University June 30-July 2, 2017 describes this event and gives an overview of the main lectures and discussions during the Congress. The latest data on the role of diet, adjuvants, vaccines, viruses and microbiome, on genetic factors, stress, smoking, lifestyle, drugs - in etiology, as well as the role of lymphocytes, macrophages, various autoantibodies, complement and cytokines - in the pathogenesis and diagnosis of autoimmune diseases were discussed. The congress discussed their comorbidity, ways of treatment and prevention, markers, methodology and contribution of serological tests in the diagnosis and classification of autoimmune diseases. Current data on physiological autoimmunity, as well as the early predictive role of autoantibodies were described. The participants performed philosophical discussions about immunological concepts, and organizational discussions of the standardization of diagnostics and the principles of working with large databases, as applied to this field. The programme included Clinical Pathophysiology все of various autoimmune rheumatologic, psycho-neurological, endocrine, cardiovascular, obstetric-gynecological and many other diseases. The authors conclude that the rapid formation of Autoimmunology as a new integral medical branch happens nowadays (9 figs, bibliography: 69 refs).

About the authors

Leonid Pavlovich Churilov

Saint Petersburg State University

Yehuda Shoenfeld

Saint Petersburg State University

References

  1. Шенфельд И., Мерони П. Л., Чурилов Л. П., ред. Руководство по аутоиммунным заболеваниям для врачей общей практики. СПб.: ЭЛБИ-Медкнига; 2017. 416.
  2. Shoenfeld Y., Blank M., Abu-Shakra M., Amital H., Barzilai O., Berkun Y., Bizzaro N., Gilburd B., Zandman-Goddard G., Katz U., Krause I., Langevitz P., Mackay I. R., Orbach H., Ram M., Sherer Y., Toubi E., Gershwin M. E. The mosaic of autoimmunity: prediction, autoantibodies and therapy in autoimmune diseases. Isr. Med. Assoc. J. 2008; 10 (1): 13-19.
  3. Agmon-Levin N., Lian Z., Shoenfeld Y. Explosion of autoimmune diseases and the mosaic of old and novel factors. Cell. Mol. Immunol. 2011; 8; 189-92.
  4. Agmon-Levin N., Shoenfeld Y. Prediction and prevention of autoimmune skin disorders. Arch. Dermatol. Res. 2008; 301: 57-64.
  5. Rubtsov A. V., Rubtsova K., Kappler J. W., Marrack P. Genetic and hormonal factors in female-biased autoimmunity. Autoimmun. Rev. 2010; 9: 494-8.
  6. Kivity S., Agmon-Levin N., Blank M., Shoenfeld Y. Infections and autoimmunity - friends or foes? Trends Immunol. 2009; 30: 409-14.
  7. Agmon-Levin N., Paz Z., Israeli E., Shoenfeld Y. Vaccines and autoimmunity. Nat. Rev. Rheumatol. 2009; 5: 648-52.
  8. Shoenfeld Y., Agmon-Levin N. «ASIA» - autoimmune/inflammatory syndrome induced by adjuvants. J. Autoimmun. 2011; 36: 4-8.
  9. Da Costa R., Szyper-Kravitz M., Szekanecz Z., Csépány T., Dankó K., Shapira Y., Zandman-Goddard G., Orbach H., Agmon-Levin N., Shoenfeld Y. Ferritin and prolactin levels in multiple sclerosis. Isr. Med. Assoc. J. 2011; 13 (2): 91-5.
  10. Praprotnik S., Agmon-Levin N., Porat-Katz B. S., Blank M., Meroni P. L., Cervera R., Miesbach W., Stojanovich L., Szyper-Kravitz M., Rozman B., Tomsic M., Shoenfeld Y. Prolactin’s role in the pathogenesis of the antiphospholipid syndrome. Lupus. 2010; 19 (13): 1515-9.
  11. Cutolo M., Pizzorni C., Sulli A. Vitamin D endocrine system involvement in autoimmune rheumatic diseases. Autoimmun. Rev. 2011; 11: 84-7.
  12. Arnson Y., Amital H., Agmon-Levin N., Alon D., Sánchez-Castañón M., López-Hoyos M., Matucci-Cerinic M., Szücs G., Shapira Y., Szekanecz Z., Shoenfeld Y. Serum 25-OH vitamin D concentrations are linked with various clinical aspects in patients with systemic sclerosis: a retrospective cohort study and review of the literature. Autoimmun. Rev. 2011; 10 (8): 490-4.
  13. Powell J. J., Faria N., Thomas-McKay E., Pele L. C. Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract. J. Autoimmun. 2010; 34: 226-33.
  14. Shen L., Matsunami Y., Quan N., Kobayashi K., Matsuura E., Oguma K. In vivo oxidation, platelet activation and simultaneous occurrence of natural immunity in atherosclerosis-prone mice. Isr. Med. Assoc. J. 2011; 13 (5): 278-83.
  15. Harari M., Dramsdahl E., Shany S., Baumfeld Y., Ingber A., Novack V., Sukenik S. Increased vitamin D serum levels correlate with clinical improvement of rheumatic diseases after Dead Sea climatotherapy. Isr. Med. Assoc. J. 2011; 13 (4): 212-5.
  16. Agmon-Levin N., Blank M., Zandman-Goddard G., Orbach H., Meroni P. L., Tincani A., Doria A., Cervera R., Miesbach W., Stojanovich L., Barak V., Porat-Katz B. S., Amital H., Shoenfeld Y. Vitamin D: an instrumental factor in the anti-phospholipid syndrome by inhibition of tissue factor expression. Ann. Rheum. Dis. 2011; 70 (1): 145-50.
  17. Selmi C., Tsuneyama K. Nutrition, geoepidemiology, and autoimmunity. Autoimmun. Rev. 2010; 9: 267-70.
  18. Lleo A., Invernizzi P., Gao B., Podda M., Gershwin M. E. Definition of human autoimmunity - autoantibodies versus autoimmune disease. Autoimmun. Rev. 2010; 9 (5): 259-66.
  19. Bassi N., Ghirardello A., Blank M., Zampieri S., Sarzi-Puttini P., Mantovani A., Shoenfeld Y., Doria A. IgG anti-pentraxin 3 antibodies in systemic lupus erythematosus. Ann. Rheum. Dis. 2010; 69 (9): 1704-10.
  20. Iobagiu C., Magyar A., Nogueira L., Cornillet M., Sebbag M., Arnaud J., Hudecz F., Serre G. The antigen specificity of the rheumatoid arthritis-associated ACPA directed to citrullinated fibrin is very closely restricted. J. Autoimmun. 2011; 37: 263-72.
  21. Leung P. S., Shu S. A., Kenny T. P., Wu P. Y., Tao M. H. Development and validation of gene therapies in autoimmune diseases: Epidemiology to animal models. Autoimmun. Rev. 2010; 9 (5): 400-5.
  22. Поземковска М., Чурилов Л. П. Илья Ильич Мечников и всемирное значение его наследия. Клин. патофизиол. 2016; 22 (3): 3-28.
  23. Zaichik A. Sh., Churilov L. P., Utekhin V. J. Autoimmune regulation of genetically determined cell functions in health and disease. Pathophysiology. 2008; 15 (3): 191-207.
  24. Первый Санкт-Петербургский конгресс по аутоиммунитету «Мост между Востоком и Западом». Доступен по: http://spbca.kenes.com/2017-en/Pages/default.aspx#.WeOhdme7Ur8 (дата обращения 15.10.2017).
  25. Dahan S., Segal Y., Watad A., Azrielant S., Shemer A., Maymon D., Stroev Y. I., Sobolevskaya P. A., Korneva E. A., Blank M., Gilburd B., Shovman O., Amital H., Ehrenfeld M., Tanay A., Kivity S., Pras E., Chapman J., Damoiseaux J., Cervera R., Putterman C., Shapiro I., Mouthon L., Periconne R., Bizzaro N., Koren O., Riemekasten G., Chereshnev V. A., Mazurov V. I., Goloviznin M. V., Gurevich V. S., Churilov L. P., Shoenfeld Y. Novelties in the Field of Autoimmunity - 1st Saint Petersburg Congress of Autoimmunity, the Bridge Between East and West. Autoim. Rev. 2017; [Epub ahead of print].
  26. Autoimmunity Network. Available at: http://www.autoimmunity-network.com/ (accessed 15.10.2017).
  27. St-Amour I., Cicchetti F., Calon F. Immunotherapies in Alzheimer’s disease: Too much, too little, too late or off-target? Acta Neuropathol. (Berl.) 2016 Apr 1; 131 (4): 481-504.
  28. Fraune J., Gerlach S., Rentzsch K., Teegen B., Lederer S., Affeldt K., Fechner K., Danckwardt M., Voigt J., Probst C., Komorowski L., Stöcker W. Multiparametric serological testing in autoimmune encephalitis using computer-aided immunofluorescence microscopy (CAIFM). Autoimmun. Rev. 2016 Oct; 15 (10): 937-42.
  29. Segal Y., Calabrò M., Kanduc D., Shoenfeld Y. Human papilloma virus and lupus: the virus, the vaccine and the disease. Cur. Opin. Rheumatol. 2017 Jul; 29 (4): 331-42.
  30. Viall C. A., Chen Q., Liu B., Hickey A., Snowise S., Salmon J. E., Stone P. R., Chamley L. W. Antiphospholipid antibodies internalised by human syncytiotrophoblast cause aberrant cell death and the release of necrotic trophoblast debris. J. Autoimmun. 2013 Dec; 47: 45-57.
  31. Derksen V. F. A. M., Huizinga T. W. J., van der Woude D. The role of autoantibodies in the pathophysiology of rheumatoid arthritis. Semin. Immunopathol. 2017; 39 (4): 437-46.
  32. Conigliaro P., Chimenti M. S., Triggianese P., Sunzini F., Novelli L., Perricone C., Perricone R. Autoantibodies in inflammatory arthritis. Autoimmun. Rev. 2016 Jul; 15 (7): 673-83.
  33. Edwards C. J., Fautrel B., Schulze-Koops H., Huizinga T. W. J., Kruger K. Dosing down with biologic therapies: a systematic review and clinicians’ perspective. Rheumatology. 2017; 10: 10-6.
  34. Пашнина И. А., Криволапова И. М., Черешнев В. А. Гуморальные иммунологические параметры у детей с ювенильным идиопатическим артритом и реактивным артритом. Российский иммунологический журнал. 2017; 11 (2): 194-7.
  35. Shovman O., Gilburd B., Chayat C., Amital H., Langevitz P., Watad A., Guy A., Perez D., Azoulay D., Blank M., Segal Y., Bentow C., Mahler M., Shoenfeld Y. Prevalence of anti-DFS70 antibodies in patients with and without systemic autoimmune rheumatic diseases. Clin. Exp. Rheumatol. 2017 Jul 27. PMID: 28770702 [Epub ahead of print]. Available at: https://www.ncbi.nlm.nih.gov/pubmed/28770702 (accessed 15.10.2017).
  36. Damoiseaux J., Csernok E., Rasmussen N., Moosig F., van Paassen P., Baslund B., Vermeersch P., Blockmans D., Tervaert J.-W. C., Bossuyt X. Detection of antineutrophil cytoplasmic antibodies (ANCAs): a multicentre European Vasculitis Study Group (EUVAS) evaluation of the value of indirect immunofluorescence (IIF) versus antigen-specific immunoassays. Ann. Rheum. Dis. 2017; 76 (4): 647-53.
  37. Van de Veen W., Stanic B., Wirz O. F., Jansen K., Globinska A., Akdis M. Role of regulatory B cells in immune tolerance to allergens and beyond. J. Allergy Clin. Immunol. 2016 Sep; 138 (3): 654-65.
  38. Poletaev A. The Natural Autoimmunity: Self-Recognition, Self-Interaction, and Self-Maintenance. J. Autoimmun. Res. 2014; 1 (1): 1001.
  39. Azrielant S., Shoenfeld Y. Eppur Si Muove: vitamin D is essential in preventing and modulating SLE. Lupus. 2016 May 1; 25 (6): 563-72.
  40. Соболевская П. А., Строев Ю. И., Утехин В. И., Чурилов Л. П. Роль гипокальциемии и витамина D3 в патогенезе фобий при хроническом аутоиммунном тироидите Хасимото. Педиатр. 2017; 8 (4): 39-42. doi: 10.17816/PED8439-42
  41. Triggianese P., Perricone C., Chimenti M. S., De Carolis C., Perricone R. Innate immune system at the maternal-fetal interface: mechanisms of disease and targets of therapy in pregnancy syndromes. Am. J. Reprod. Immunol. 2016; 76 (4): 245-57.
  42. D’Aurizio F., Villalta D., Metus P., Doretto P., Tozzoli R. Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases? Autoimmun. Rev. 2015; 14 (5): 363-9.
  43. Churilov L., Stroev Yu. I., Serdyuk I. Y., Kaminova-Mudzhikova O., Belyaeva I., Gvozdetsky A., Mikhailova L. R. Autoimmune thyroiditis: Centennial jubilee of a social disease and its comorbidity. Pathophysiology. 2014; 21 (2): 135-45.
  44. Chalmers S. A., Doerner J., Bosanac T., Khalil S., Smith D., Harcken C., Dimock J., Der E., Herlitz L., Webb D., Seccareccia E., Feng D., Fine J. S., Ramanujam M., Klein E., Putterman C. Therapeutic blockade of immune complex-mediated glomerulonephritis by highly selective inhibition of Bruton’s tyrosine kinase. Sci. Rep. 2016; 6: 26164.
  45. Katz-Agranov N., Zandman-Goddard G. The microbiome and systemic lupus erythematosus. Immunol. Res. 2017; 65 (2): 432-7.
  46. Arango M.-T., Perricone C., Kivity S., Cipriano E., Ceccarelli F., Valesini G., Shoenfeld Y. HLA-DRB1 the notorious gene in the mosaic of autoimmunity. Immunol. Res. 2017 Feb; 65 (1): 82-98.
  47. Ballanti E., Perricone C., Greco E., Ballanti M., Di Muzio G., Chimenti M. S., Perricone R. Complement and autoimmunity. Immunol. Res. 2013; 56 (2-3): 477-91.
  48. Dahan S., Segal Y., Shoenfeld Y. Dietary factors in rheumatic autoimmune diseases: a recipe for therapy? Nat. Rev. Rheumatol. 2017; 13 (6): 348-58.
  49. Rybakina E. G., Shanin S. N., Korneva E. A. Cellular, molecular and signaling mechanisms in neuro-immune interactions under stress. Adv. Neuroimmune. Biol. 2012; 3: 235-41.
  50. Luigi B. N., Watad A., Adawi M., Amital H., Aljadeff G., Shoenfeld Y. Adjuvants and Autoimmunity: Why Do We Develop Autoantibodies, Autoimmune Diseases and Lymphomas. Isr. Med. Assoc. J. IMAJ. 2017; 19 (7): 403.
  51. Maijers M. C., de Blok C. J. M., Niessen F. B., van der Veldt A. A. M., Ritt M. J. P. F., Winters H. A. H., Kramer M. H., Nanayakkara P. W. Women with silicone breast implants and unexplained systemic symptoms: A descriptive cohort study. Neth. J. Med. 2013; 71: 534-40.
  52. Silva-Fernández L., Lunt M., Kearsley-Fleet L., Watson K. D., Dixon W. G., Symmons D. P., Hyrich K. L. The incidence of cancer in patients with rheumatoid arthritis and a prior malignancy who receive TNF inhibitors or rituximab: results from the British Society for Rheumatology Biologics Register-Rheumatoid Arthritis. Rheumatology. 2016; 55 (11): 2033-9.
  53. Tozzoli R., Villalta D., Bizzaro N. Challenges in the standardization of autoantibody testing: a comprehensive review. Clin. Rev. Allergy. Immunol. 2017; 53 (1): 68-77.
  54. Насонов Е. Л., Александрова Е. Н., Новиков А. А. Аутоиммунные ревматические заболевания - проблемы иммунопатологии и персонализованного лечения. Вестник РАМН, 2015; (2): 169-82.
  55. Shovman O., Gilburd B., Chayat C., Lazar A. D., Amital H., Blank M., Bentow C., Mahler M., Shoenfeld Y. Anti-HMGCR antibodies demonstrate high diagnostic value in the diagnosis of immune-mediated necrotizing myopathy following statin exposure. Immunol. Res. 2017; 65 (1): 276-81.
  56. Dumoitier N., Chaigne B., Régent A., Lofek S., Mhibik M., Dorfmüller P., Terrier B., London J., Bérezné A., Tamas N., Varin-Blank N., Mouthon L. Scleroderma Peripheral B Lymphocytes Secrete Interleukin-6 and Transforming Growth Factor β and Activate Fibroblasts. Arthritis Rheumatol. 2017 May; 69 (5): 1078-89. doi: 10.1002/art.40016
  57. Cabral-Marques O., Riemekasten G. Vascular hypothesis revisited: Role of stimulating antibodies against angiotensin and endothelin receptors in the pathogenesis of systemic sclerosis. Autoimmun. Rev. 2016; 15 (7): 690-4.
  58. Shor D. B.-A., Dahan S., Comaneshter D., Cohen A. D., Amital H. Does inflammatory bowel disease coexist with systemic lupus erythematosus? Autoimmun. Rev. 2016; 15 (11): 1034-7.
  59. Versini M., Jeandel P.-Y., Bashi T., Bizzaro G., Blank M., Shoenfeld Y. Unraveling the hygiene hypothesis of helminthes and autoimmunity: origins, pathophysiology, and clinical applications. BMC Med. 2015; 13 (1): 81.
  60. Zuercher A. W., Spirig R., Baz Morelli A., Käsermann F. IVIG in autoimmune disease - Potential next generation biologics. Autoimmun. Rev. 2016 Aug; 15 (8): 781-5.
  61. Clarke S. F., Murphy E. F., O’Sullivan O., Lucey A. J., Humphreys M., Hogan A., Hayes P., O'Reilly M., Jeffery I. B., Wood-Martin R., Kerins D. M., Quigley E., Ross R. P., O'Toole P. W., Molloy M. G., Falvey E., Shanahan F., Cotter P. D. Exercise and associated dietary extremes impact on gut microbial diversity. Gut. 2014; 63 (12): 1913-20.
  62. Tauber A. Metchnikoff’s Radicalism. Clin. Pathophysiol. 2016; 23 (3): 28-37.
  63. Perricone C., Versini M., Ben-Ami D., Gertel S., Watad A., Segel M. J., Ceccarelli F., Conti F., Cantarini L., Bogdanos D. P., Antonelli A., Amital H., Valesini G., Shoenfeld Y. Smoke and autoimmunity: The fire behind the disease. Autoimmun. Rev. 2016 Apr; 15 (4): 354-74. doi: 10.1016/j.autrev.2016.01.001
  64. Katz D., Katz I., Porat-Katz B. S., Shoenfeld Y. Medical cannabis: Another piece in the mosaic of autoimmunity? Clin. Pharmacol. Ther. 2017 Feb; 101 (2): 230-8. doi: 10.1002/cpt.568
  65. Torres-Ruiz J., Sulli A., Cutolo M., Shoenfeld Y. Air Travel, Circadian Rhythms/Hormones, and Autoimmunity. Clin. Rev. Allergy Immunol. 2017 Aug; 53 (1): 117-25. doi: 10.1007/s12016-017-8599-2
  66. Gurevich V. S. Influenza, autoimmunity and atherogenesis. Autoimmun. Rev. 2005 Feb; 4 (2): 101-5.
  67. George J., Afek A., Gilburd B., Harats D., Shoenfeld Y. Autoimmunity in atherosclerosis: lessons from experimental models. Lupus. 2000; 9 (3): 223-7.
  68. Baptista B., Casian A., Gunawardena H., D'Cruz D., Rice C. M. Neurological Manifestations of IgG4-Related Disease. Curr. Treat. Options Neurol. 2017 Apr; 19 (4): 14. doi: 10.1007/s11940-017-0450-9
  69. th International Congress on Autoimmunity. Lisbon, Portugal, 18-20 May 2018. Available at: http://autoimmunity.kenes.com/2018/registration/register-here#.WcmfkdMcwr8 (accessed 16.10.2017).

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