低温氩等离子体对乳腺癌放射治疗阶段患者神经肌肉系统电兴奋性的影响
- 作者: Kozyreva V.O.1, Evstigneeva I.S.1
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隶属关系:
- Russian Medical Academy of Continuous Professional Education
- 期: 卷 23, 编号 5 (2024)
- 页面: 281-291
- 栏目: Original studies
- URL: https://journals.rcsi.science/1681-3456/article/view/279885
- DOI: https://doi.org/10.17816/rjpbr642390
- ID: 279885
如何引用文章
详细
背景。放射治疗是乳腺癌治疗的重要阶段,但可能引发副作用,例如放射性皮炎和纤维化,这对上肢功能产生负面影响并降低患者的生活质量。预防放射反应和纤维化需要多学科综合方法。目前,已证实综合医学康复,包括物理治疗方法、心理矫正、治疗性体操和营养支持的效果,但有关低温氩等离子体应用的研究仍不足。
研究目的。确定低温氩等离子体对乳腺癌放射治疗阶段患者神经肌肉系统电兴奋性的影响。
材料与方法。研究纳入了60名乳腺癌放疗阶段的女性患者。所有患者均接受综合医学康复,包括全身磁疗、治疗性体操、基于生物反馈平台的支撑反应训练、营养支持及心理矫正。主组患者(n=30)额外接受了低温氩等离子体治疗。结果通过视觉模拟评分(Visual Analog Scale, VAS)、放射治疗肿瘤学组(Radiation Therapy Oncology Group, RTOG)利用“Eleskulap-Med TeKo”刺激与电疗设备(俄罗斯“Med TeKo”,注册证书编号 № FSR 2011/09988,签发日期:2011年2月4日)进行电兴奋性研究。
结果。在放疗和综合医学康复结束后,主组和未接受低温氩等离子体治疗的对照组患者之间,RTOG评分中放射反应严重程度的差异具有统计学意义(p=0.016)。同时,在胸大肌(m. pectoralis major)的胸骨肋部(pars sternocostalis)和锁骨部(pars clavicularis)的电兴奋性指标中也观察到统计学显著差异。
结论。低温氩等离子体的应用有助于减轻乳腺癌放射治疗阶段患者神经肌肉系统的功能障碍。
作者简介
Valeria O. Kozyreva
Russian Medical Academy of Continuous Professional Education
编辑信件的主要联系方式.
Email: kvo03@yandex.ru
ORCID iD: 0000-0002-1103-704X
SPIN 代码: 6936-0576
Graduate Student
俄罗斯联邦, MoscowInna S. Evstigneeva
Russian Medical Academy of Continuous Professional Education
Email: evstigneevais@mail.ru
ORCID iD: 0000-0001-9128-0965
SPIN 代码: 5163-7726
MD, Cand. Sci. (Medicine), Associate Professor
俄罗斯联邦, Moscow参考
- Rasskazova ЕА, Zikiryakhodzhaev AD. De-escalation of radiation therapy in the treatment plan of patients with stage I-IIV breast cancer after subcutaneous/skin-sparing mastectomies with immediate reconstruction. Creative surgery and oncology. 2024;14(3):235–242. (In Russ.) doi: 10.24060/2076-3093-2024-14-3-235-242
- Park SY, Kim JH, Chang JH, et al. Quantitative evaluation of radiodermatitis following whole-breast radiotherapy with various color space models: A feasibility study. PLoS One. 2022;17(3):e0264925. doi: 10.1371/journal.pone.0264925
- Leonardis JM, Lulic-Kuryllo T, Lipps DB. The impact of local therapies for breast cancer on shoulder muscle health and function. Crit Rev Oncol Hematol. 2022;177:103759. doi: 10.1016/j.critrevonc.2022.103759
- Balaeva DA, Romanov DS, Trofimova OP, et al. Radiation injuries of organs and tissues: mechanisms of occurrence, methods of prevention and treatment: A review. Journal of Modern Oncology. 2023;25(4):504–512. (In Russ.) doi: 10.26442/18151434.2023.4.202572
- Wei J, Meng L, Hou X, et al. Radiation-induced skin reactions: mechanism and treatment. Cancer Manag Res. 2018;11:167–177. doi: 10.2147/CMAR.S188655
- Lang AE, Dickerson CR, Kim SY, et al. Impingement pain affects kinematics of breast cancer survivors in work-related functional tasks. Clinical Biomechanics. 2019;70:223–230. doi: 10.1016/j.clinbiomech.2019.10.001
- Belysheva TS, Valiev TT, Shatokhina EA, et al. Radiation dermatitis: current view on pathogenesis, principles of profilaxis and treatment. Russian Journal of Pediatric Hematology and Oncology. 2022;9(4):81–87. (In Russ.) doi: 10.21682/2311-1267-2022-9-4-81-87
- Vavilov MP, Kizhayev YeV, Kusevich MN. Post-radiation post-mastectomy syndrome: aspects of evidence-based medicine. Tumors of the female reproductive system. 2008;(2):7–11. (In Russ.)
- Akhtemzyanov AR, Pinyaeva SM, Nikolaeva EN, Emileva TE. Experience in correcting skin radiation reactionswith basic care products. Clinical observation. Meditsinskiy Sovet. 2022;16(9):193–198. (In Russ.) doi: 10.21518/2079-701X-2022-16-9-193-198
- Konchugova TV, Apkhanova TV, Kulchitskaya DB, et al. Current aspects of medical rehabilitation of patients with cancer related lymphedema of extremities: a narrative review. Bulletin of Rehabilitation Medicine. 2024;23(1):66–76. (In Russ.) doi: 10.38025/2078-1962-2024-23-1-66-76
- Klimova MO, Gladkov YuO. Psychological features of women undergoing sectoral resection or mastectomy for breast cancer. Society: Sociology, Psychology, Pedagogics. 2024;(1):98–105. (In Russ.) doi: 10.24158/spp.2024.1.10
- Orlov II, Grushina TI. Efficiency of therapeutic gymnastics as one of the methods of rehabilitation of breast cancer patients with impaired volume and freedom of movement in the shoulder joint. Modern Issues of Biomedicine. 2024;8(1). (In Russ.) doi: 10.24412/2588-0500-2024_08_01_25
- Stepanova AM, Gameeva EV, Germanova OV, Ognev YuN. Modern technologies of rehabilitation of cancer patients: a review of international experience. Malignant tumors. 2022;12(3s1):48–56. (In Russ). doi: 10.18027/2224-5057-2022-12-3s1-48-56
- Sýtov AV, Zuzov SA, Kukosh MYu, et al. Practical recommendations on nutritional support for cancer patients. Malignant tumors: Practical recommendations of RUSSCO. 2022;12(3s2):123–133. (In Russ.) doi: 10.18027/2224-5057-2021-11-3s2-43
- Evstigneeva IS, Gerasimenko MYu. Algorithms for choosing physiotherapy in patients with mastopathy during adjuvant radiation therapy. Resort medicine. 2024;3:27–37. (In Russ.) doi: 10.24412/2304-0343-2024_3_27
- Ma L, Chen Y, Gong Q, et al. Cold atmospheric plasma alleviates radiation-induced skin injury by suppressing inflammation and promoting repair. Free Radic Biol Med. 2023;1(204):184–194. doi: 10.1016/j.freeradbiomed.2023.05.002
- Dejonckheere CS, Torres-Crigna A, Layer JP, et al. Non-Invasive Physical Plasma for Preventing Radiation Dermatitis in Breast Cancer: A First-In-Human Feasibility Study. Pharmaceutics. 2022;14(9):17–67. doi: 10.3390/pharmaceutics14091767
- Shixkerimov RK, Savin AA, Vel'sher LZ, et al. The pathology of brachial neuro-vascular bundle in clinical manifestations of postmastectomy syndrome. Vestnik Natsional’nogo medico-khirurgicheskogo centra im. N.I. Pirogova. 2011;6(4):86–90. (In Russ.) EDN: ROPACL
