Enviar artigo por via de e-mail Synthesis of magnetic silica nanomarkers with controlled physicochemical properties
- Autores: Zelepukin I.V.1,2,3, Nikitin M.P.1,3,4, Cherkasov V.R.3, Nikitin P.I.4, Deyev S.M.1,2, Petrov P.V.1
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Afiliações:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Nizhny Novgorod State University
- Moscow Institute of Physics and Technology (State University)
- Prokhorov Institute of General Physics
- Edição: Volume 470, Nº 1 (2016)
- Páginas: 335-337
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211555
- DOI: https://doi.org/10.1134/S1607672916050100
- ID: 211555
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Resumo
Magnetic markers which can be detected with an extremely high sensitivity with the method of magnetic particle quantification (MPQ) were synthesized. Using a controlled Stober reaction, a set of magnetic silica markers of different sizes and zeta potentials was obtained. The use of a carboxymethyl dextran polymer to stabilize the magnetite particles during the synthesis made it possible to substantially reduce the detection limit of the obtained construct, which opens up new opportunities for creating effective diagnostic nanoagents.
Sobre autores
I. Zelepukin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Nizhny Novgorod State University; Moscow Institute of Physics and Technology (State University)
Autor responsável pela correspondência
Email: zelepukin@phystech.edu
Rússia, ul. Miklukho-Maklaya 16/10, Moscow, 117997; pr. Gagarina 23, Nizhny Novgorod, 630600; Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700
M. Nikitin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Moscow Institute of Physics and Technology (State University); Prokhorov Institute of General Physics
Email: zelepukin@phystech.edu
Rússia, ul. Miklukho-Maklaya 16/10, Moscow, 117997; Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700; ul. Vavilova 38, Moscow, 119991
V. Cherkasov
Moscow Institute of Physics and Technology (State University)
Email: zelepukin@phystech.edu
Rússia, Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700
P. Nikitin
Prokhorov Institute of General Physics
Email: zelepukin@phystech.edu
Rússia, ul. Vavilova 38, Moscow, 119991
S. Deyev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Nizhny Novgorod State University
Email: zelepukin@phystech.edu
Rússia, ul. Miklukho-Maklaya 16/10, Moscow, 117997; pr. Gagarina 23, Nizhny Novgorod, 630600
P. Petrov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: zelepukin@phystech.edu
Rússia, ul. Miklukho-Maklaya 16/10, Moscow, 117997
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