Synthesis of magnetic silica nanomarkers with controlled physicochemical properties


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Magnetic markers which can be detected with an extremely high sensitivity with the method of magnetic particle quantification (MPQ) were synthesized. Using a controlled Stober reaction, a set of magnetic silica markers of different sizes and zeta potentials was obtained. The use of a carboxymethyl dextran polymer to stabilize the magnetite particles during the synthesis made it possible to substantially reduce the detection limit of the obtained construct, which opens up new opportunities for creating effective diagnostic nanoagents.

作者简介

I. Zelepukin

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Nizhny Novgorod State University; Moscow Institute of Physics and Technology (State University)

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Email: zelepukin@phystech.edu
俄罗斯联邦, ul. Miklukho-Maklaya 16/10, Moscow, 117997; pr. Gagarina 23, Nizhny Novgorod, 630600; Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700

M. Nikitin

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Moscow Institute of Physics and Technology (State University); Prokhorov Institute of General Physics

Email: zelepukin@phystech.edu
俄罗斯联邦, ul. Miklukho-Maklaya 16/10, Moscow, 117997; Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700; ul. Vavilova 38, Moscow, 119991

V. Cherkasov

Moscow Institute of Physics and Technology (State University)

Email: zelepukin@phystech.edu
俄罗斯联邦, Institutskii per. 9, Dolgoprudnyi, Moscow oblast, 141700

P. Nikitin

Prokhorov Institute of General Physics

Email: zelepukin@phystech.edu
俄罗斯联邦, ul. Vavilova 38, Moscow, 119991

S. Deyev

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Nizhny Novgorod State University

Email: zelepukin@phystech.edu
俄罗斯联邦, ul. Miklukho-Maklaya 16/10, Moscow, 117997; pr. Gagarina 23, Nizhny Novgorod, 630600

P. Petrov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry

Email: zelepukin@phystech.edu
俄罗斯联邦, ul. Miklukho-Maklaya 16/10, Moscow, 117997

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