Отправить статью по E-mail Expression of senescence-associated genes in multipotent mesenchymal stromal cells during long-term cultivation at various hypoxic levels
- Авторы: Lobanova M.V.1, Ratushnyy A.Y.1, Buravkova L.B.1
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Учреждения:
- Institute of Biomedical Problems
- Выпуск: Том 470, № 1 (2016)
- Страницы: 326-328
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211536
- DOI: https://doi.org/10.1134/S1607672916050057
- ID: 211536
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Аннотация
The expression of several genes which functions are associated with cellular senescence was analyzed in multipotent mesenchymal stromal cells during long-term cultivation at different oxygen levels (20, 5, and 1%) using the RT² Profiler™ PCR Array Human Cellular Senescence system (Qiagen, United States). It was established that replicative senescence processes develop most actively in the cells cultured under the standard conditions (20% O2). The most significant changes were observed in the expression of CCND1, ID1, IGF1, PIK3CA, and SERPINE1 genes.
Об авторах
M. Lobanova
Institute of Biomedical Problems
Автор, ответственный за переписку.
Email: pogodina_m@mail.ru
Россия, Khoroshevskoe sh. 76-a, Moscow, 123007
A. Ratushnyy
Institute of Biomedical Problems
Email: pogodina_m@mail.ru
Россия, Khoroshevskoe sh. 76-a, Moscow, 123007
L. Buravkova
Institute of Biomedical Problems
Email: pogodina_m@mail.ru
Россия, Khoroshevskoe sh. 76-a, Moscow, 123007
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