Low-Molecular-Weight Compound GSB-106 Mimics the Cellular Effects of BDNF after Serum Deprivation
- Авторы: Zainullina L.F.1, Gudasheva T.A.1, Vakhitova Y.V.1, Seredenin S.B.1
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Учреждения:
- Zakusov Research Institute of Pharmacology
- Выпуск: Том 489, № 1 (2019)
- Страницы: 396-398
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213126
- DOI: https://doi.org/10.1134/S1607672919060139
- ID: 213126
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Аннотация
The in vitro model of serum deprivation shows that the survival of SH-SY5Y neuronal cells is ensured by the intrinsic trophic activity of BDNF loop 4 mimetic GSB-106 (10–7 М), which is comparable to that of endogenous neurotrophin (10–9 М). The analysis of the cell cycle and S-phase showed that GSB-106, similarly to BDNF, induces the cell-cycle arrest in the G1 phase, diminishes the number of cells in the S-phase, reduces the number of apoptotic cells, and does not stimulate proliferation.
Об авторах
L. Zainullina
Zakusov Research Institute of Pharmacology
Email: juvv73@gmail.com
Россия, ul. Baltiiskaya 8, Moscow, 125315
T. Gudasheva
Zakusov Research Institute of Pharmacology
Email: juvv73@gmail.com
Россия, ul. Baltiiskaya 8, Moscow, 125315
Yu. Vakhitova
Zakusov Research Institute of Pharmacology
Автор, ответственный за переписку.
Email: juvv73@gmail.com
Россия, ul. Baltiiskaya 8, Moscow, 125315
S. Seredenin
Zakusov Research Institute of Pharmacology
Email: juvv73@gmail.com
Россия, ul. Baltiiskaya 8, Moscow, 125315
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