Email this article Low-Molecular-Weight Compound GSB-106 Mimics the Cellular Effects of BDNF after Serum Deprivation
- Authors: Zainullina L.F.1, Gudasheva T.A.1, Vakhitova Y.V.1, Seredenin S.B.1
-
Affiliations:
- Zakusov Research Institute of Pharmacology
- Issue: Vol 489, No 1 (2019)
- Pages: 396-398
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213126
- DOI: https://doi.org/10.1134/S1607672919060139
- ID: 213126
Cite item
Open Access
Access granted
Subscription Access
Abstract
The in vitro model of serum deprivation shows that the survival of SH-SY5Y neuronal cells is ensured by the intrinsic trophic activity of BDNF loop 4 mimetic GSB-106 (10–7 М), which is comparable to that of endogenous neurotrophin (10–9 М). The analysis of the cell cycle and S-phase showed that GSB-106, similarly to BDNF, induces the cell-cycle arrest in the G1 phase, diminishes the number of cells in the S-phase, reduces the number of apoptotic cells, and does not stimulate proliferation.
About the authors
L. F. Zainullina
Zakusov Research Institute of Pharmacology
Email: juvv73@gmail.com
Russian Federation, ul. Baltiiskaya 8, Moscow, 125315
T. A. Gudasheva
Zakusov Research Institute of Pharmacology
Email: juvv73@gmail.com
Russian Federation, ul. Baltiiskaya 8, Moscow, 125315
Yu. V. Vakhitova
Zakusov Research Institute of Pharmacology
Author for correspondence.
Email: juvv73@gmail.com
Russian Federation, ul. Baltiiskaya 8, Moscow, 125315
S. B. Seredenin
Zakusov Research Institute of Pharmacology
Email: juvv73@gmail.com
Russian Federation, ul. Baltiiskaya 8, Moscow, 125315
Supplementary files
