The inhibitors of Arp2/3 complex and WASP proteins modulate the effect of glutoxim on Na+ transport in frog skin
- Autores: Krutetskaya Z.I.1, Melnitskaya A.V.1, Antonov V.G.1, Nozdrachev A.D.1
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Afiliações:
- St. Petersburg State University
- Edição: Volume 467, Nº 1 (2016)
- Páginas: 102-104
- Seção: Biochemistry, Biophysics and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211031
- DOI: https://doi.org/10.1134/S1607672916020071
- ID: 211031
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Resumo
Using voltage-clamp technique, the involvement of WASP proteins and Arp2/3 complex in the effect of immunomodulator drug glutoxim on Na+ transport in frog skin was investigated. It was shown for the first time that preincubation of the skin with the N-WASP inhibitor wiskostatin or the Arp2/3 complex inhibitor CK-0944666 significantly decreases the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of actin filament polymerization and branching in the glutoxim effect on Na+ transport in frog skin.
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Sobre autores
Z. Krutetskaya
St. Petersburg State University
Autor responsável pela correspondência
Email: zk@bio.spbu.ru
Rússia, Universitetskaya nab. 7/9, St. Petersburg, 199034
A. Melnitskaya
St. Petersburg State University
Email: zk@bio.spbu.ru
Rússia, Universitetskaya nab. 7/9, St. Petersburg, 199034
V. Antonov
St. Petersburg State University
Email: zk@bio.spbu.ru
Rússia, Universitetskaya nab. 7/9, St. Petersburg, 199034
A. Nozdrachev
St. Petersburg State University
Email: zk@bio.spbu.ru
Rússia, Universitetskaya nab. 7/9, St. Petersburg, 199034
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