The inhibitors of Arp2/3 complex and WASP proteins modulate the effect of glutoxim on Na+ transport in frog skin

Аннотация

Using voltage-clamp technique, the involvement of WASP proteins and Arp2/3 complex in the effect of immunomodulator drug glutoxim on Na⁺ transport in frog skin was investigated. It was shown for the first time that preincubation of the skin with the N-WASP inhibitor wiskostatin or the Arp2/3 complex inhibitor CK-0944666 significantly decreases the stimulatory effect of glutoxim on Na⁺ transport. The data suggest the involvement of actin filament polymerization and branching in the glutoxim effect on Na⁺ transport in frog skin.