Enviar artigo por via de e-mail Potassium Salt of Fullerenylpenta-N-Dihydroxytyrosine Effects on Type 2 Diabetes Mellitus Therapeutic Targets
- Autores: Soldatova Y.V.1,2, Kotelnikova R.A.1, Zhilenkov A.V.1, Faingold I.I.1,2, Troshin P.A.1,3, Kozlova M.A.2, Areshidze D.A.1,2, Aldoshin S.M.1
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Afiliações:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Moscow Region State University
- Skolkovo Institute of Science and Technology
- Edição: Volume 488, Nº 1 (2019)
- Páginas: 320-323
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213087
- DOI: https://doi.org/10.1134/S1607672919050089
- ID: 213087
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Resumo
It was shown for the first time that pentaamino acid derivative of fullerene C60 (potassium salt of fullerenylpenta-N-dihydroxytyrosine) affects three targets of type 2 diabetes mellitus. It competitively inhibits the enzymes aldose reductase and sorbitol dehydrogenase and also has an antiglycation effect on bovine serum albumin. The inhibition constants for these enzymes were calculated.
Sobre autores
Yu. Soldatova
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Moscow Region State University
Autor responsável pela correspondência
Email: soldatovayv@gmail.com
Rússia, Chernogolovka, Moscow oblast, 142432; Moscow
R. Kotelnikova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: soldatovayv@gmail.com
Rússia, Chernogolovka, Moscow oblast, 142432
A. Zhilenkov
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: soldatovayv@gmail.com
Rússia, Chernogolovka, Moscow oblast, 142432
I. Faingold
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Moscow Region State University
Email: soldatovayv@gmail.com
Rússia, Chernogolovka, Moscow oblast, 142432; Moscow
P. Troshin
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Skolkovo Institute of Science and Technology
Email: soldatovayv@gmail.com
Rússia, Chernogolovka, Moscow oblast, 142432; Moscow, 143025
M. Kozlova
Moscow Region State University
Email: soldatovayv@gmail.com
Rússia, Moscow
D. Areshidze
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Moscow Region State University
Email: soldatovayv@gmail.com
Rússia, Chernogolovka, Moscow oblast, 142432; Moscow
S. Aldoshin
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: soldatovayv@gmail.com
Rússia, Chernogolovka, Moscow oblast, 142432
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