Effect of New Derivatives of 2-Aminothiophene-3-Carboxylic Acid on Calcium-Activated Chloride Currents in Rat Neurons

V. V. Grigoriev; V. L. Zamoyski; A. V. Aksinenko; V. B. Sokolov; S. O. Bachurin

doi:10.1134/S1607672918060042

Effect of New Derivatives of 2-Aminothiophene-3-Carboxylic Acid on Calcium-Activated Chloride Currents in Rat Neurons

Authors: Grigoriev V.V.¹, Zamoyski V.L.¹, Aksinenko A.V.¹, Sokolov V.B.¹, Bachurin S.O.¹
Affiliations:
1. Institute of Physiologically Active Compounds
Issue: Vol 483, No 1 (2018)
Pages: 293-296
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/212512
DOI: https://doi.org/10.1134/S1607672918060042
ID: 212512

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Abstract

Using the patch-clamp method in the whole-cell configuration, we showed that the new derivatives of 2-aminothiophene-3-carboxylic acid, which were synthesized by us earlier, can both block (compound 1) and potentiate (compound 2) calcium-activated chloride currents in single rat cerebellar Purkinje cells.