Effect of New Derivatives of 2-Aminothiophene-3-Carboxylic Acid on Calcium-Activated Chloride Currents in Rat Neurons
- Авторы: Grigoriev V.V.1, Zamoyski V.L.1, Aksinenko A.V.1, Sokolov V.B.1, Bachurin S.O.1
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Учреждения:
- Institute of Physiologically Active Compounds
- Выпуск: Том 483, № 1 (2018)
- Страницы: 293-296
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/212512
- DOI: https://doi.org/10.1134/S1607672918060042
- ID: 212512
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Аннотация
Using the patch-clamp method in the whole-cell configuration, we showed that the new derivatives of 2-aminothiophene-3-carboxylic acid, which were synthesized by us earlier, can both block (compound 1) and potentiate (compound 2) calcium-activated chloride currents in single rat cerebellar Purkinje cells.
Об авторах
V. Grigoriev
Institute of Physiologically Active Compounds
Email: vzam@yandex.ru
Россия, Chernogolovka, Moscow oblast, 142432
V. Zamoyski
Institute of Physiologically Active Compounds
Автор, ответственный за переписку.
Email: vzam@yandex.ru
Россия, Chernogolovka, Moscow oblast, 142432
A. Aksinenko
Institute of Physiologically Active Compounds
Email: vzam@yandex.ru
Россия, Chernogolovka, Moscow oblast, 142432
V. Sokolov
Institute of Physiologically Active Compounds
Email: vzam@yandex.ru
Россия, Chernogolovka, Moscow oblast, 142432
S. Bachurin
Email: vzam@yandex.ru
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