Antitumor efficacy of Auger electron emitter 111In delivered by modular nanotransporter into the nuclei of cells with folate receptor overexpression
- Autores: Rosenkranz A.A.1,2, Slastnikova T.A.1, Khramtsov Y.V.1, Karyagina T.S.1, Georgiev G.P.1, Sobolev A.S.1,2
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Afiliações:
- Institute of Gene Biology
- Faculty of Biology
- Edição: Volume 473, Nº 1 (2017)
- Páginas: 85-87
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211847
- DOI: https://doi.org/10.1134/S1607672917020016
- ID: 211847
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Resumo
A new modular nanotransporter (MNT) for the delivery of anticancer agents into the nuclei of cells with folate receptor overexpression was created. An effective method for acceding labeling of this MNT with Auger electron emitter 111In has been developed. A significant therapeutic effect was observed after a single intratumoral injection of the new 111In-labeled MNT to mice grafted with human cervical carcinoma characterized by folate receptor overexpression.
Sobre autores
A. Rosenkranz
Institute of Gene Biology; Faculty of Biology
Email: sobolev@igb.ac.ru
Rússia, Moscow, 119334; Moscow, 119992
T. Slastnikova
Institute of Gene Biology
Email: sobolev@igb.ac.ru
Rússia, Moscow, 119334
Yu. Khramtsov
Institute of Gene Biology
Email: sobolev@igb.ac.ru
Rússia, Moscow, 119334
T. Karyagina
Institute of Gene Biology
Email: sobolev@igb.ac.ru
Rússia, Moscow, 119334
G. Georgiev
Institute of Gene Biology
Email: sobolev@igb.ac.ru
Rússia, Moscow, 119334
A. Sobolev
Institute of Gene Biology; Faculty of Biology
Autor responsável pela correspondência
Email: sobolev@igb.ac.ru
Rússia, Moscow, 119334; Moscow, 119992
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