Antitumor efficacy of Auger electron emitter 111In delivered by modular nanotransporter into the nuclei of cells with folate receptor overexpression


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Resumo

A new modular nanotransporter (MNT) for the delivery of anticancer agents into the nuclei of cells with folate receptor overexpression was created. An effective method for acceding labeling of this MNT with Auger electron emitter 111In has been developed. A significant therapeutic effect was observed after a single intratumoral injection of the new 111In-labeled MNT to mice grafted with human cervical carcinoma characterized by folate receptor overexpression.

Sobre autores

A. Rosenkranz

Institute of Gene Biology; Faculty of Biology

Email: sobolev@igb.ac.ru
Rússia, Moscow, 119334; Moscow, 119992

T. Slastnikova

Institute of Gene Biology

Email: sobolev@igb.ac.ru
Rússia, Moscow, 119334

Yu. Khramtsov

Institute of Gene Biology

Email: sobolev@igb.ac.ru
Rússia, Moscow, 119334

T. Karyagina

Institute of Gene Biology

Email: sobolev@igb.ac.ru
Rússia, Moscow, 119334

G. Georgiev

Institute of Gene Biology

Email: sobolev@igb.ac.ru
Rússia, Moscow, 119334

A. Sobolev

Institute of Gene Biology; Faculty of Biology

Autor responsável pela correspondência
Email: sobolev@igb.ac.ru
Rússia, Moscow, 119334; Moscow, 119992

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