Antitumor efficacy of Auger electron emitter  111 In delivered by modular nanotransporter into the nuclei of cells with folate receptor overexpression

A. A. Rosenkranz; T. A. Slastnikova; Yu. V. Khramtsov; T. S. Karyagina; G. P. Georgiev; A. S. Sobolev

doi:10.1134/S1607672917020016

Antitumor efficacy of Auger electron emitter ¹¹¹In delivered by modular nanotransporter into the nuclei of cells with folate receptor overexpression

作者: Rosenkranz A.A.¹^,2, Slastnikova T.A.¹, Khramtsov Y.V.¹, Karyagina T.S.¹, Georgiev G.P.¹, Sobolev A.S.¹^,2
隶属关系:
1. Institute of Gene Biology
2. Faculty of Biology
期: 卷 473, 编号 1 (2017)
页面: 85-87
栏目: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/211847
DOI: https://doi.org/10.1134/S1607672917020016
ID: 211847

如何引用文章

全文:

开放存取

##reader.subscriptionAccessGranted##
受限制的访问

订阅存取

详细
作者简介
参考
补充文件
统计

详细

A new modular nanotransporter (MNT) for the delivery of anticancer agents into the nuclei of cells with folate receptor overexpression was created. An effective method for acceding labeling of this MNT with Auger electron emitter ¹¹¹In has been developed. A significant therapeutic effect was observed after a single intratumoral injection of the new ¹¹¹In-labeled MNT to mice grafted with human cervical carcinoma characterized by folate receptor overexpression.