Email this article Mechanism of caspase-2 activation upon DNA damage
- Authors: Aksenova V.I.1, Kopeina G.S.1, Zamaraev A.V.1, Zhivotovsky B.D.1,2, Lavrik I.N.1,2
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Affiliations:
- Faculty of Basic Medicine
- Department of Translational Inflammation, Institute of Experimental Internal Medicine
- Issue: Vol 467, No 1 (2016)
- Pages: 132-135
- Section: Biochemistry, Biophysics and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211074
- DOI: https://doi.org/10.1134/S1607672916020150
- ID: 211074
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Abstract
The mechanism of caspase-2 activation in response to DNA damage was studied using human ovarian cancer cells Caov-4 treated with chemotherapeutic agent cisplatin. It was shown that mutations of the three cleavage sites of caspase-2 do not affect the assembly of the macromolecular complex of caspase-2 and its activation, but, conversely, stabilize this complex, most likely, via the inhibition of the dissociation of the active caspase-2.
About the authors
V. I. Aksenova
Faculty of Basic Medicine
Email: gelina@rambler.ru
Russian Federation, Lomonosovsky pr. 31/5, Moscow, 119991
G. S. Kopeina
Faculty of Basic Medicine
Author for correspondence.
Email: gelina@rambler.ru
Russian Federation, Lomonosovsky pr. 31/5, Moscow, 119991
A. V. Zamaraev
Faculty of Basic Medicine
Email: gelina@rambler.ru
Russian Federation, Lomonosovsky pr. 31/5, Moscow, 119991
B. D. Zhivotovsky
Faculty of Basic Medicine; Department of Translational Inflammation, Institute of Experimental Internal Medicine
Email: gelina@rambler.ru
Russian Federation, Lomonosovsky pr. 31/5, Moscow, 119991; Magdeburg
I. N. Lavrik
Faculty of Basic Medicine; Department of Translational Inflammation, Institute of Experimental Internal Medicine
Email: gelina@rambler.ru
Russian Federation, Lomonosovsky pr. 31/5, Moscow, 119991; Magdeburg
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