电邮这篇文章 Mechanism of caspase-2 activation upon DNA damage
- 作者: Aksenova V.I.1, Kopeina G.S.1, Zamaraev A.V.1, Zhivotovsky B.D.1,2, Lavrik I.N.1,2
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隶属关系:
- Faculty of Basic Medicine
- Department of Translational Inflammation, Institute of Experimental Internal Medicine
- 期: 卷 467, 编号 1 (2016)
- 页面: 132-135
- 栏目: Biochemistry, Biophysics and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211074
- DOI: https://doi.org/10.1134/S1607672916020150
- ID: 211074
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详细
The mechanism of caspase-2 activation in response to DNA damage was studied using human ovarian cancer cells Caov-4 treated with chemotherapeutic agent cisplatin. It was shown that mutations of the three cleavage sites of caspase-2 do not affect the assembly of the macromolecular complex of caspase-2 and its activation, but, conversely, stabilize this complex, most likely, via the inhibition of the dissociation of the active caspase-2.
作者简介
V. Aksenova
Faculty of Basic Medicine
Email: gelina@rambler.ru
俄罗斯联邦, Lomonosovsky pr. 31/5, Moscow, 119991
G. Kopeina
Faculty of Basic Medicine
编辑信件的主要联系方式.
Email: gelina@rambler.ru
俄罗斯联邦, Lomonosovsky pr. 31/5, Moscow, 119991
A. Zamaraev
Faculty of Basic Medicine
Email: gelina@rambler.ru
俄罗斯联邦, Lomonosovsky pr. 31/5, Moscow, 119991
B. Zhivotovsky
Faculty of Basic Medicine; Department of Translational Inflammation, Institute of Experimental Internal Medicine
Email: gelina@rambler.ru
俄罗斯联邦, Lomonosovsky pr. 31/5, Moscow, 119991; Magdeburg
I. Lavrik
Faculty of Basic Medicine; Department of Translational Inflammation, Institute of Experimental Internal Medicine
Email: gelina@rambler.ru
俄罗斯联邦, Lomonosovsky pr. 31/5, Moscow, 119991; Magdeburg
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