Enviar artigo por via de e-mail Dimeric Disintegrins from the Steppe Viper V. ursinii Venom
- Autores: Kryukova E.V.1, Potapenko A.S.1, Andreeva T.V.1, Ivanov I.A.1, Ryabinin V.V.1, Ziganshin R.H.1, Starkov V.G.1, Ayvazyan N.M.2, Tsetlin V.I.1, Utkin Y.N.1
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Afiliações:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Orbeli Institute of Physiology, National Academy of Sciences of the Republic of Armenia
- Edição: Volume 488, Nº 1 (2019)
- Páginas: 338-341
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213095
- DOI: https://doi.org/10.1134/S1607672919050132
- ID: 213095
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Resumo
Four dimeric disintegrins were isolated from the venom of the steppe viper V. ursinii using liquid chromatography. Disintegrins prevented adhesion of MCF7 cells to fibronectin, which indicates their interaction with integrin receptors of the αVβ1 type. According to mass spectrometry data, the molar masses of disintegrins are about 14 kDa. The method of peptide mapping established the structure of a new heterodimeric disintegrin weighing 13 995.5 Da and shows that it belongs to the class of RGD/KGD-containing disintegrins.
Sobre autores
E. Kryukova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Autor responsável pela correspondência
Email: evkr@mail.ru
Rússia, Moscow, 117997
A. Potapenko
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Rússia, Moscow, 117997
T. Andreeva
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Rússia, Moscow, 117997
I. Ivanov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Rússia, Moscow, 117997
V. Ryabinin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Rússia, Moscow, 117997
R. Ziganshin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Rússia, Moscow, 117997
V. Starkov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Rússia, Moscow, 117997
N. Ayvazyan
Orbeli Institute of Physiology, National Academy of Sciences of the Republic of Armenia
Email: evkr@mail.ru
Armênia, Yerevan, 0019
V. Tsetlin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Rússia, Moscow, 117997
Yu. Utkin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Rússia, Moscow, 117997
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