Отправить статью по E-mail Dimeric Disintegrins from the Steppe Viper V. ursinii Venom
- Авторы: Kryukova E.V.1, Potapenko A.S.1, Andreeva T.V.1, Ivanov I.A.1, Ryabinin V.V.1, Ziganshin R.H.1, Starkov V.G.1, Ayvazyan N.M.2, Tsetlin V.I.1, Utkin Y.N.1
-
Учреждения:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Orbeli Institute of Physiology, National Academy of Sciences of the Republic of Armenia
- Выпуск: Том 488, № 1 (2019)
- Страницы: 338-341
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213095
- DOI: https://doi.org/10.1134/S1607672919050132
- ID: 213095
Цитировать
Открытый доступ
Доступ предоставлен
Только для подписчиков
Аннотация
Four dimeric disintegrins were isolated from the venom of the steppe viper V. ursinii using liquid chromatography. Disintegrins prevented adhesion of MCF7 cells to fibronectin, which indicates their interaction with integrin receptors of the αVβ1 type. According to mass spectrometry data, the molar masses of disintegrins are about 14 kDa. The method of peptide mapping established the structure of a new heterodimeric disintegrin weighing 13 995.5 Da and shows that it belongs to the class of RGD/KGD-containing disintegrins.
Об авторах
E. Kryukova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: evkr@mail.ru
Россия, Moscow, 117997
A. Potapenko
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Россия, Moscow, 117997
T. Andreeva
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Россия, Moscow, 117997
I. Ivanov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Россия, Moscow, 117997
V. Ryabinin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Россия, Moscow, 117997
R. Ziganshin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Россия, Moscow, 117997
V. Starkov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Россия, Moscow, 117997
N. Ayvazyan
Orbeli Institute of Physiology, National Academy of Sciences of the Republic of Armenia
Email: evkr@mail.ru
Армения, Yerevan, 0019
V. Tsetlin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Россия, Moscow, 117997
Yu. Utkin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Россия, Moscow, 117997
Дополнительные файлы
