Мақаланы E-mail арқылы жіберу Detection of human neuronal α7 nicotinic acetylcholine receptors by conjugates of snake α-neurotoxin with quantum dots
- Авторлар: Makarova Y.V.1, Shelukhina I.V.1, Mukherjee A.K.2, Kuznetsov D.V.3, Tsetlin V.I.1, Utkin Y.N.1,3
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Мекемелер:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Tezpur University
- The National University of Science and Technology MISiS
- Шығарылым: Том 475, № 1 (2017)
- Беттер: 253-255
- Бөлім: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211939
- DOI: https://doi.org/10.1134/S1607672917040032
- ID: 211939
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Аннотация
Fluorescent derivatives are widely used to study the structure and functions of proteins. Quantum dots (QDs), fluorescent semiconductor nanocrystals, have a high quantum yield and are much more resistant to bleaching compared to organic dyes. Conjugates of α-neurotoxins with QDs were used for visualization of human α7 acetylcholine receptors heterologously expressed in GH4C1 pituitary adenoma cells. Specific staining of cells by the conjugated toxins was observed.
Авторлар туралы
Ya. Makarova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: utkin@mx.ibch.ru
Ресей, Moscow, 117997
I. Shelukhina
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: utkin@mx.ibch.ru
Ресей, Moscow, 117997
A. Mukherjee
Tezpur University
Email: utkin@mx.ibch.ru
Үндістан, Tezpur
D. Kuznetsov
The National University of Science and Technology MISiS
Email: utkin@mx.ibch.ru
Ресей, Moscow, 119049
V. Tsetlin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: utkin@mx.ibch.ru
Ресей, Moscow, 117997
Yu. Utkin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; The National University of Science and Technology MISiS
Хат алмасуға жауапты Автор.
Email: utkin@mx.ibch.ru
Ресей, Moscow, 117997; Moscow, 119049
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