Enviar artigo por via de e-mail Detection of human neuronal α7 nicotinic acetylcholine receptors by conjugates of snake α-neurotoxin with quantum dots
- Autores: Makarova Y.V.1, Shelukhina I.V.1, Mukherjee A.K.2, Kuznetsov D.V.3, Tsetlin V.I.1, Utkin Y.N.1,3
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Afiliações:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Tezpur University
- The National University of Science and Technology MISiS
- Edição: Volume 475, Nº 1 (2017)
- Páginas: 253-255
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211939
- DOI: https://doi.org/10.1134/S1607672917040032
- ID: 211939
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Resumo
Fluorescent derivatives are widely used to study the structure and functions of proteins. Quantum dots (QDs), fluorescent semiconductor nanocrystals, have a high quantum yield and are much more resistant to bleaching compared to organic dyes. Conjugates of α-neurotoxins with QDs were used for visualization of human α7 acetylcholine receptors heterologously expressed in GH4C1 pituitary adenoma cells. Specific staining of cells by the conjugated toxins was observed.
Sobre autores
Ya. Makarova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: utkin@mx.ibch.ru
Rússia, Moscow, 117997
I. Shelukhina
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: utkin@mx.ibch.ru
Rússia, Moscow, 117997
A. Mukherjee
Tezpur University
Email: utkin@mx.ibch.ru
Índia, Tezpur
D. Kuznetsov
The National University of Science and Technology MISiS
Email: utkin@mx.ibch.ru
Rússia, Moscow, 119049
V. Tsetlin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: utkin@mx.ibch.ru
Rússia, Moscow, 117997
Yu. Utkin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; The National University of Science and Technology MISiS
Autor responsável pela correspondência
Email: utkin@mx.ibch.ru
Rússia, Moscow, 117997; Moscow, 119049
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