Enviar artigo por via de e-mail Peroxide-Induced Oxidative Modification of Hemoglobin
- Autores: Vasilyeva A.D.1, Yurina L.V.1, Bugrova A.E.1, Indeykina M.I.1,2, Azarova D.Y.1,3, Bychkova A.V.1, Akzhigitova K.I.1,4, Kononikhin A.S.1,5,2, Nikolaev E.N.1,5,6, Rosenfeld M.A.1
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Afiliações:
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Moscow Institute of Physics and Technology
- Skryabin Moscow State Academy of Veterinary Medicine, and Biotechnology
- Belinsky Pedagogical Institute, Penza State University
- Tal’roze Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences
- Skolkovo Institute of Science and Technology
- Edição: Volume 486, Nº 1 (2019)
- Páginas: 197-200
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213012
- DOI: https://doi.org/10.1134/S1607672919030116
- ID: 213012
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Resumo
The oxidative modification of human hemoglobin (Hb) treated with hydrogen peroxide was investigated. Using the mass spectrometry method, the oxidized amino acid residues of the hemoglobin molecule were detected: αTrp14, αTyr24, αArg31, αMet32, αTyr42, αHis45, αHis72, αMet76, αPro77, αLys90, αCys104, αTyr140, βHis2, βTrp15, βTrp37, βMet55, βCys93, βCys112, βTyr130, βLys144, and βHis146. The antioxidant potential of the Hb molecule in the intracellular space and in the blood plasma is discussed.
Sobre autores
A. Vasilyeva
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Autor responsável pela correspondência
Email: ms.kadaver@mail.ru
Rússia, Moscow, 119334
L. Yurina
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: ms.kadaver@mail.ru
Rússia, Moscow, 119334
A. Bugrova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: ms.kadaver@mail.ru
Rússia, Moscow, 119334
M. Indeykina
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Moscow Institute of Physics and Technology
Email: ms.kadaver@mail.ru
Rússia, Moscow, 119334; Dolgoprudnyi, Moscow oblast, 141701
D. Azarova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Skryabin Moscow State Academy of Veterinary Medicine, and Biotechnology
Email: ms.kadaver@mail.ru
Rússia, Moscow, 119334; Moscow
A. Bychkova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: ms.kadaver@mail.ru
Rússia, Moscow, 119334
K. Akzhigitova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Belinsky Pedagogical Institute, Penza State University
Email: ms.kadaver@mail.ru
Rússia, Moscow, 119334; Penza
A. Kononikhin
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Tal’roze Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences; Moscow Institute of Physics and Technology
Email: ms.kadaver@mail.ru
Rússia, Moscow, 119334; Moscow, 119334; Dolgoprudnyi, Moscow oblast, 141701
E. Nikolaev
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Tal’roze Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences; Skolkovo Institute of Science and Technology
Email: ms.kadaver@mail.ru
Rússia, Moscow, 119334; Moscow, 119334; Skolkovo, Moscow oblast, 143025
M. Rosenfeld
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: ms.kadaver@mail.ru
Rússia, Moscow, 119334
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