Influence of dicarbonyls on kinetic characteristics of glutathione peroxidase


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Se-containing glutathione peroxidase (GSH-Px) is one of the key enzymes of the body’s antioxidant system. The kinetic characteristics of GSH-Px (substrate is tert-butyl hydroperoxide) after modification of the enzyme by various concentrations of natural dicarbonyls (glyoxal, methylglyoxal, malonic dialdehyde) were studied. It was shown that dicarbonyls affected both Km and Vmax for GSH-Px. It is suggested that the effect of various dicarbonyls on GSH-Px depends on the molecular mechanisms of their interaction with the amino acid residues of the enzyme.

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V. Lankin

Russian Cardiology Research and Production Center

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Email: lankin941@mail.ru
俄罗斯联邦, Moscow, 121552

K. Shumaev

Russian Cardiology Research and Production Center; Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology”

Email: lankin941@mail.ru
俄罗斯联邦, Moscow, 121552; Moscow, 119071

A. Tikhaze

Russian Cardiology Research and Production Center

Email: lankin941@mail.ru
俄罗斯联邦, Moscow, 121552

B. Kurganov

Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology”

Email: lankin941@mail.ru
俄罗斯联邦, Moscow, 119071

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