Мақаланы E-mail арқылы жіберу Influence of dicarbonyls on kinetic characteristics of glutathione peroxidase
- Авторлар: Lankin V.Z.1, Shumaev K.B.1,2, Tikhaze A.K.1, Kurganov B.I.2
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Мекемелер:
- Russian Cardiology Research and Production Center
- Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology”
- Шығарылым: Том 475, № 1 (2017)
- Беттер: 287-290
- Бөлім: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/211960
- DOI: https://doi.org/10.1134/S1607672917040123
- ID: 211960
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Аннотация
Se-containing glutathione peroxidase (GSH-Px) is one of the key enzymes of the body’s antioxidant system. The kinetic characteristics of GSH-Px (substrate is tert-butyl hydroperoxide) after modification of the enzyme by various concentrations of natural dicarbonyls (glyoxal, methylglyoxal, malonic dialdehyde) were studied. It was shown that dicarbonyls affected both Km and Vmax for GSH-Px. It is suggested that the effect of various dicarbonyls on GSH-Px depends on the molecular mechanisms of their interaction with the amino acid residues of the enzyme.
Авторлар туралы
V. Lankin
Russian Cardiology Research and Production Center
Хат алмасуға жауапты Автор.
Email: lankin941@mail.ru
Ресей, Moscow, 121552
K. Shumaev
Russian Cardiology Research and Production Center; Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology”
Email: lankin941@mail.ru
Ресей, Moscow, 121552; Moscow, 119071
A. Tikhaze
Russian Cardiology Research and Production Center
Email: lankin941@mail.ru
Ресей, Moscow, 121552
B. Kurganov
Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology”
Email: lankin941@mail.ru
Ресей, Moscow, 119071
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