Exogenous heat shock protein HSP70 reduces response of human neuroblastoma cells to lipopolysaccharide


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The effect of exogenous heat shock protein HSP70 and lipopolysaccharide (LPS) on the production of reactive oxygen species (ROS), TNFα secretion, and mRNA expression by human neuroblastoma SK-N-SH cells. It was shown that exogenous HSP70 protects neuroblastoma cells from the action of LPS. The protection mechanism of HSP70 includes a reduction in the production of ROS and TNFα and a decrease in the expression of TLR4 and IL-1β mRNA in SK-N-SH cells induced by LPS.

Sobre autores

M. Yurinskaya

Institute of Cell Biophysics; Engelhardt Institute of Molecular Biology

Email: mg-vinokurov@mail.ru
Rússia, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290; ul. Vavilova 32, Moscow, 119991

S. Funikov

Engelhardt Institute of Molecular Biology

Email: mg-vinokurov@mail.ru
Rússia, ul. Vavilova 32, Moscow, 119991

M. Evgen’ev

Institute of Cell Biophysics; Engelhardt Institute of Molecular Biology

Email: mg-vinokurov@mail.ru
Rússia, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290; ul. Vavilova 32, Moscow, 119991

M. Vinokurov

Institute of Cell Biophysics

Autor responsável pela correspondência
Email: mg-vinokurov@mail.ru
Rússia, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290

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